5mafesh | 1210843-95-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: 5mafesh
• 英文别名: 5'-methyl-2'-hydroxyacetophenone ethanesulfonylhydrazone
• CAS: 1210843-95-0
• 化学式: C₁₁H₁₆N₂O₃S
• 分子量: 256.326
• InChiKey: BLGBZWSVCPFWFW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.36
• 重原子数：
  17.0
• 可旋转键数：
  4.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  78.76
• 氢给体数：
  2.0
• 氢受体数：
  4.0

反应信息

• 作为反应物：
  描述：

  5mafesh 、 nickel dichloride 在 sodium hydroxide 作用下， 以 甲醇 、 乙腈 为溶剂， 以45%的产率得到[Ni(5-methyl-2-hydroxyacetophenoneethane sulfohydrazone(-1H))2]
  参考文献：
  名称：

  Synthesis, characterization, antibacterial activities and carbonic anhydrase enzyme inhibitor effects of new arylsulfonylhydrazone and their Ni(II), Co(II) complexes

  摘要：

  Ethane sulfonic acide hydrazide (esh: CH3CH2SO2NHNH2) derivatives as 5-methylsalicyl-aldehyde-ethanesulfonylhydrazone (5msalesh), 5-methyl-2-hydroxyacetophenoneethane sulfonylhydrazone (5mafesh) and their Ni(II), Co(II) complexes have been synthesized for the first time. The Structure of these compounds has been investigated by elemental analysis, FT-IR, H-1 NMR, C-13 NMR, LC/MS, UV-vis spectrophotometric method, magnetic Susceptibility, thermal studies and conductivity measurements. The antibacterial activities of synthesized compounds were studied against Grain positive bacteria: Staphylococcus aureus, Bacillus subtilis, Bacillus magaterium and Gram negative bacteria; Salmonella enteritidis, Escherichia coli by using the microdilution broth method. The biological activity screening showed that ligands have more activity than complexes against the tested bacteria. The inhibition activities of these compounds on carbonic anhydrase II (CA II) have been investigated by comparing IC50 and K-i values and it has been found that 5msalesh and its complexes have more enzyme inhibition efficiency than other compounds. (C) 2009 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.saa.2009.09.052
• 作为产物：
  描述：

  2-羟基-5-甲基苯乙酮 、 ethylsulfonyl hydrazide 以 乙醇 为溶剂， 反应 1.0h， 以55%的产率得到5mafesh
  参考文献：
  名称：

  Synthesis, characterization, antibacterial activities and carbonic anhydrase enzyme inhibitor effects of new arylsulfonylhydrazone and their Ni(II), Co(II) complexes

  摘要：

  Ethane sulfonic acide hydrazide (esh: CH3CH2SO2NHNH2) derivatives as 5-methylsalicyl-aldehyde-ethanesulfonylhydrazone (5msalesh), 5-methyl-2-hydroxyacetophenoneethane sulfonylhydrazone (5mafesh) and their Ni(II), Co(II) complexes have been synthesized for the first time. The Structure of these compounds has been investigated by elemental analysis, FT-IR, H-1 NMR, C-13 NMR, LC/MS, UV-vis spectrophotometric method, magnetic Susceptibility, thermal studies and conductivity measurements. The antibacterial activities of synthesized compounds were studied against Grain positive bacteria: Staphylococcus aureus, Bacillus subtilis, Bacillus magaterium and Gram negative bacteria; Salmonella enteritidis, Escherichia coli by using the microdilution broth method. The biological activity screening showed that ligands have more activity than complexes against the tested bacteria. The inhibition activities of these compounds on carbonic anhydrase II (CA II) have been investigated by comparing IC50 and K-i values and it has been found that 5msalesh and its complexes have more enzyme inhibition efficiency than other compounds. (C) 2009 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.saa.2009.09.052
• 作为试剂：
  描述：

  4-硝基苯基乙酸酯 在 5mafesh 、 carbonic anhydrase II 作用下， 反应 0.02h， 生成 对硝基苯酚
  参考文献：
  名称：

  Synthesis, characterization, antibacterial activities and carbonic anhydrase enzyme inhibitor effects of new arylsulfonylhydrazone and their Ni(II), Co(II) complexes

  摘要：

  Ethane sulfonic acide hydrazide (esh: CH3CH2SO2NHNH2) derivatives as 5-methylsalicyl-aldehyde-ethanesulfonylhydrazone (5msalesh), 5-methyl-2-hydroxyacetophenoneethane sulfonylhydrazone (5mafesh) and their Ni(II), Co(II) complexes have been synthesized for the first time. The Structure of these compounds has been investigated by elemental analysis, FT-IR, H-1 NMR, C-13 NMR, LC/MS, UV-vis spectrophotometric method, magnetic Susceptibility, thermal studies and conductivity measurements. The antibacterial activities of synthesized compounds were studied against Grain positive bacteria: Staphylococcus aureus, Bacillus subtilis, Bacillus magaterium and Gram negative bacteria; Salmonella enteritidis, Escherichia coli by using the microdilution broth method. The biological activity screening showed that ligands have more activity than complexes against the tested bacteria. The inhibition activities of these compounds on carbonic anhydrase II (CA II) have been investigated by comparing IC50 and K-i values and it has been found that 5msalesh and its complexes have more enzyme inhibition efficiency than other compounds. (C) 2009 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.saa.2009.09.052