5-(6-methyl-1,2,4,5-tetrazin-3-yl)pentan-1-amine | 1225266-52-3

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 5-(6-methyl-1,2,4,5-tetrazin-3-yl)pentan-1-amine
• CAS: 1225266-52-3
• 化学式: C₈H₁₅N₅
• 分子量: 181.241
• InChiKey: GDPXFDGABMDKIV-UHFFFAOYSA-N

物化性质

• 沸点：
  364.0±44.0 °C(Predicted)
• 密度：
  1.100±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.6
• 重原子数：
  13
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  77.6
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• COMPOSITIONS AND METHODS FOR DELIVERING A SUBSTANCE TO A BIOLOGICAL TARGET
  申请人：The General Hospital Corporation

  公开号：EP3622968A1

  公开（公告）日：2020-03-18

  The present application provides compositions and methods using bioorthogonal inverse electron demand Diels-Alder cycloaddition reaction for rapid and specific covalent delivery of a "payload" to a ligand bound to a biological target.

  本申请提供了一种使用生物正交反向电子需求Diels-Alder环加成反应的组合物和方法，用于快速和特异性地将“有效载荷”共价地传递给结合在生物靶点上的配体。
• CLICK-CROSSLINKED HYDROGELS AND METHODS OF USE
  申请人：President and Fellows of Harvard College

  公开号：US20170189581A1

  公开（公告）日：2017-07-06

  The present disclosure provides click-crosslinked hydrogels and methods of use.

  本公开提供了点击交联水凝胶及其使用方法。
• FUNCTIONALIZED 1,2,4,5-TETRAZINE COMPOUNDS FOR USE IN BIOORTHOGONAL COUPLING REACTIONS
  申请人：DEVARAJ Neal K.

  公开号：US20150246893A1

  公开（公告）日：2015-09-03

  The present application relates to functionalized 1,2,4,5-tetrazine compounds. The compounds are useful in compositions and methods using bioorthogonal inverse electron demand Diels-Alder cycloaddition reactions for the rapid and specific covalent delivery of a “payload” to a ligand bound to a biological target.

  本申请涉及功能化的1,2,4,5-四唑化合物。这些化合物在使用生物正交反电子需求Diels-Alder环加成反应的组合物和方法中非常有用，以实现快速和特异性的共价传递“有效负载”到结合于生物靶标的配体。
• OXIDIZED POLYSACCHARIDES AND METHODS OF USE THEREOF
  申请人：President and Fellows of Harvard College

  公开号：EP3821880A1

  公开（公告）日：2021-05-19

  The present invention is directed to reduced and highly oxidized polysaccharides, such as alginates, that are useful for encapsulating therapeutic or diagnostic agents, or lipid based nanoparticles, e.g., liposomes or virosomes, encapsulating therapeutic or diagnostic agents, prior to their delivery into a subject, as well as methods for making and using them.

  本发明涉及可用于封装治疗或诊断药物的还原多糖和高度氧化多糖（如藻酸盐），或用于封装治疗或诊断药物的脂基纳米颗粒（如脂质体或病毒体），然后再将其输送到受试者体内，以及制造和使用它们的方法。
• Reduced and oxidized polysaccharides and methods of use thereof
  申请人：President and Fellows of Harvard College

  公开号：US10780171B2

  公开（公告）日：2020-09-22

  The present invention is directed to reduced and highly oxidized polysaccharides, such as alginates, that are useful for encapsulating therapeutic or diagnostic agents, or lipid based nanoparticles, e.g., liposomes or virosomes, encapsulating therapeutic or diagnostic agents, prior to their delivery into a subject, as well as methods for making and using them.

  本发明涉及可用于封装治疗或诊断药物的还原多糖和高度氧化多糖（如藻酸盐），或用于封装治疗或诊断药物的脂基纳米颗粒（如脂质体或病毒体），然后再将其输送到受试者体内，以及制造和使用它们的方法。