2,3,N,N-Tetramethyl-2-butylamin | 29773-00-0

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 2,3,N,N-Tetramethyl-2-butylamin
• 英文别名: N,N,1,1,2-Pentamethylpropylamin；Dimethyl-(1,1,2-trimethyl-propyl)-amin；N,N,2,3-tetramethylbutan-2-amine
• CAS: 29773-00-0
• 化学式: C₈H₁₉N
• 分子量: 129.246
• InChiKey: GIYIPFNEKOGFFX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.2
• 重原子数：
  9
• 可旋转键数：
  2
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  聚合甲醛 、 2,3-dimethyl-2-butylamine 在 甲酸 作用下， 生成 2,3,N,N-Tetramethyl-2-butylamin
  参考文献：
  名称：

  Vejdelek,Z.J. et al., Collection of Czechoslovak Chemical Communications, 1970, vol. 35, p. 2814 - 2830

  摘要：

  DOI：

文献信息

• [EN] QUINOLONE DERIVATIVES AS FIBROBLAST GROWTH FACTOR RECEPTOR INHIBITORS<br/>[FR] DÉRIVÉS DE QUINOLONE UTILISÉS EN TANT QU'INHIBITEURS DU RÉCEPTEUR DU FACTEUR DE CROISSANCE DES FIBROBLASTES
  申请人：PRINCIPIA BIOPHARMA INC

  公开号：WO2016191172A1

  公开（公告）日：2016-12-01

  Compounds of formula (I) that are Fibroblast Growth Factor Inhibitors (FGFR) and are therefore useful for the treatment of diseases treatable by inhibition of FGFR are disclosed. Also disclosed are pharmaceutical compositions containing such compounds and processes for preparing such compounds.

  公式(I)的化合物是成纤维细胞生长因子抑制剂（FGFR），因此可用于治疗可通过抑制FGFR治疗的疾病。还披露了包含此类化合物的药物组合物以及制备此类化合物的过程。
• Purinone Derivatives as Tyrosine Kinase Inhibitors
  申请人：Principia Biopharma Inc.

  公开号：US20140142099A1

  公开（公告）日：2014-05-22

  The present disclosure provides compounds and pharmaceutically acceptable salts thereof that are tyrosine kinase inhibitors, in particular BLK, BMX, EGFR, HER2, HER4, ITK, TEC, BTK, and TXK and are therefore useful for the treatment of diseases treatable by inhibition of tyrosine kinases such as autoimmune diseases, cancer and inflammatory diseases. Also provided are pharmaceutical compositions containing such compounds and pharmaceutically acceptable salts thereof and processes for preparing such compounds and pharmaceutically acceptable salts thereof.

  本公开提供了一些酪氨酸激酶抑制剂及其药用盐，特别是BLK、BMX、EGFR、HER2、HER4、ITK、TEC、BTK和TXK，因此适用于治疗通过抑制酪氨酸激酶可治疗的疾病，如自身免疫疾病、癌症和炎症性疾病。还提供了含有这些化合物和药用盐的药物组合物，以及制备这些化合物和药用盐的方法。
• NOVEL POLYMERIC PHOTOINITIATORS AND PHOTOINITIATOR MONOMERS
  申请人：Colopast A/S

  公开号：US20150166716A1

  公开（公告）日：2015-06-18

  The present invention provides polymeric photoinitiators being co-polymers of photoinitiator monomers and at least one further monomer, as well as the photoinitiator monomers being intermediates in the preparation of such polymeric photoinitiators. Additionally there is provided polyacrylate obtained by radical polymerization of at least one acrylate monomer (Ac) in the presence of such polymeric photoinitiators. In the photoinitiator monomers and polymeric photoinitiators, a photoinitiator moiety and a tertiary amine are incorporated into the photoinitiator structure.

  本发明提供了聚合光引发剂，其为光引发剂单体和至少一种其他单体的共聚物，同时所述光引发剂单体为制备这种聚合光引发剂的中间体。此外，本发明还提供了通过在存在这种聚合光引发剂的情况下，通过至少一种丙烯酸酯单体（Ac）的自由基聚合获得的聚丙烯酸酯。在光引发剂单体和聚合光引发剂中，光引发剂基团和三级胺被结合到光引发剂结构中。
• AZO-SUBSTITUTED PYRIDINE AND PYRIMIDINE DERIVATIVES AND THEIR USE IN TREATING VIRAL INFECTIONS
  申请人：Kwong Cecil D.

  公开号：US20110286964A1

  公开（公告）日：2011-11-24

  The present invention provides compounds of Formula (I): (Chemical formula should be inserted here as it appears on abstract in paper form) (I) and tautomers, isomers, and esters of said compounds, and pharmaceutically acceptable salts, solvates, and prodrugs of said compounds, wherein each of R, R 1 , X, Y, Z, R 2 , R 3 , R 4 , R 5 , R 6 , R 7 , R 8 , R 9 , R 18 , R 19 , and n is selected independently and as defined herein. Compositions comprising such compounds are also provided. The compounds of the invention are effective as inhibitors of HCV, and are useful, alone and together with other therapeutic agents, in treating or preventing dieases or disorders such as viral infections and virus-related disorders.

  本发明提供了式(I)的化合物：（将在论文中以纸质形式出现的化学式插入此处）（I）及其互变异构体、异构体和酯类，以及所述化合物的药学上可接受的盐、溶剂化物和前药，其中每个R、R1、X、Y、Z、R2、R3、R4、R5、R6、R7、R8、R9、R18、R19和n均是独立选择并如所定义。还提供了包含此类化合物的组合物。本发明的化合物是HCV抑制剂，可用于治疗或预防病毒感染和与病毒相关的疾病或障碍，单独或与其他治疗剂一起使用。
• ANTIVIRAL COMPOUNDS
  申请人：Bacon Elizabeth

  公开号：US20140039021A1

  公开（公告）日：2014-02-06

  The invention is related to anti-viral compounds, compositions containing such compounds, and therapeutic methods that include the administration of such compounds, as well as to processes and intermediates useful for preparing such compounds.

  该发明涉及抗病毒化合物、含有这些化合物的组合物以及包括这些化合物的治疗方法，以及用于制备这些化合物的有用过程和中间体。