3',6'-dihydroxy-4,5,6,7-tetraiodo-spiro[phthalan-1,9'-xanthen]-3-one | 109421-23-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: 3',6'-dihydroxy-4,5,6,7-tetraiodo-spiro[phthalan-1,9'-xanthen]-3-one
• 英文别名: 3',6'-Dihydroxy-4,5,6,7-tetrajod-spiro[phthalan-1,9'-xanthen]-3-on；tetraiodofluorescein；Spiro[isobenzofuran-1(3H),9'-[9h]xanthen]-3-one,3',6'-dihydroxy-2',4',5',7'-tetraiodo-,radical ion(1-)(9ci)；3',6'-dihydroxy-4,5,6,7-tetraiodospiro[2-benzofuran-3,9'-xanthene]-1-one
• CAS: 109421-23-0
• 化学式: C₂₀H₈I₄O₅
• 分子量: 835.899
• InChiKey: QQZFJHUMDRYDEG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6
• 重原子数：
  29
• 可旋转键数：
  0
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  76
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  甲醇 、 3',6'-dihydroxy-4,5,6,7-tetraiodo-spiro[phthalan-1,9'-xanthen]-3-one 生成 alkaline earth salt of/the/ methylsulfuric acid
  参考文献：
  名称：

  Pratt; Coleman, Journal of the American Chemical Society, 1918, vol. 40, p. 242

  摘要：

  DOI：
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 生成 3',6'-dihydroxy-4,5,6,7-tetraiodo-spiro[phthalan-1,9'-xanthen]-3-one
  参考文献：
  名称：

  Pratt; Coleman, Journal of the American Chemical Society, 1918, vol. 40, p. 242

  摘要：

  DOI：
• 作为试剂：
  描述：

  (22E)-3β-acetoxy-5α-ergosta-7,14,22-triene 在 乙醇 、 3',6'-dihydroxy-4,5,6,7-tetraiodo-spiro[phthalan-1,9'-xanthen]-3-one 作用下， 生成 3β-acetoxy-7α,8-epoxy-5α,8α,14ξ-ergost-22t-en-15-one
  参考文献：
  名称：

  ergosta-7：14：22-trien-3β-乙酸乙烯酯的某些氧化产物（乙酸麦角甾醇b 3）

  摘要：

  DOI：

  10.1039/jr9540000052

文献信息

• Compositions for accelerated tooth-whitening
  申请人：Cameron B. Ryan

  公开号：US20050249679A1

  公开（公告）日：2005-11-10

  Dual-component tooth-whitening systems are disclosed comprising a peroxygen whitening agent in the first component and a transition metal catalyst along with an alkaline compound in the second component. Also disclosed are tooth-whitening methods based upon the systems.

  本发明公开了双组分牙齿美白系统，第一组分包含一种过氧化物美白剂，第二组分则包含一种过渡金属催化剂和一种碱性化合物。同时也公开了基于该系统的牙齿美白方法。
• [EN] A NOVEL POLYMER, A COMPOSITION, A METHOD AND A KIT FOR WHITENING TEETH<br/>[FR] NOUVEAU POLYMÈRE, COMPOSITION, PROCÉDÉ ET KIT POUR BLANCHIR LES DENTS
  申请人：UNILEVER NV

  公开号：WO2020001864A1

  公开（公告）日：2020-01-02

  The present invention relates to a novel polymer for use in an oral care composition for whitening teeth. The invention also relates to a process to prepare the polymer and a kit that contains the composition and a source of light. The polymer is characterized by including a xanthene dye moiety attached therein.

  本发明涉及一种新型聚合物，用于口腔护理组合物中美白牙齿。该发明还涉及制备聚合物的过程以及包含组合物和光源的套件。该聚合物的特点是包含一个联结在其中的黄色染料基团。
• [EN] PROCESS FOR THE SYNTHESIS OF 4,5,6,7-TETRACHLORO-3',6'-DIHYDROXY-2',4',5'7'-TETRAIODO-3H-SPIRO[ISOBENZOFURAN-1,9'-XANTHEN]-3-ONE (ROSE BENGAL) AND RELATED XANTHENES<br/>[FR] PROCÉDÉ DE SYNTHÈSE DE 4,5,6,7-TÉTRACHLORO-3',6'-DIHYDROXY-2',4',5'7'-TÉTRAÏODO-3H-SPIRO[ISOBENZOFURAN-1,9'-XANTHEN]-3-ONE (ROSE BENGALE) ET DE XANTHÈNES APPARENTÉS
  申请人：PROVECTUS PHARMACEUTICALS INC

  公开号：WO2011035161A1

  公开（公告）日：2011-03-24

  A new process for the manufacture of iodinated xanthenes in high purity includes a cyclization step followed by an iodination step. No extraction, chromatographic or solvent concentration steps are required, and the intermediate as well as final compounds are isolated via filtration or similar means. The process requires a single organic solvent, and the steps are completed at temperatures below 100°C. The exclusion of chloride ions, of chloride free-radicals, hypochlorite ions, or hypochlorous acid as reagents or from reagents that may generate these species in situ in the presence of oxidants, prevents undesirable impurity formation. Several new compounds have been conceived and isolated using these methods. These new compounds are also formed into new medicaments.

  一种制备高纯度碘代黄色素的新工艺包括环化步骤和碘化步骤。不需要萃取、色谱或溶剂浓缩步骤，中间体和最终化合物均通过过滤或类似手段分离。该工艺需要单一有机溶剂，并且步骤在100℃以下完成。排除氯离子、自由氯自由基、次氯酸盐离子或次氯酸作为试剂或从可能在氧化剂存在下生成这些物种的试剂中排除，可以防止不良杂质形成。使用这些方法已经构思并分离出几种新化合物。这些新化合物也被制成了新药物。
• Radiation-sensitive polymers
  申请人：POLYTECHNIC UNIVERSITY

  公开号：EP0210056A2

  公开（公告）日：1987-01-28

  This invention relates to the preparation of solvent soluble polymeric materials which become insoluble in solvents after exposure to actinic light, x-rays or electron beams. The polymers are linear block copolymers comprising two segments; a soft segment which form a continuous phase, and a rigid, crystallizable photoreactive segment which forms a dispersed phase. The rigid segments may be chosen from polyurethanes, polyesters, polyamides, and polyureas which contain a diacetylene group in their repeat units. The soft segments are low molecular weight rubbery polymers which may be selected from groups such as polyethers, polyesters, polydienes, and polysiloxanes. The polymers produced are useful in a wide variety of applications in the field of coatings and graphic arts. More particularly, this invention relates to negative photoresists which are remarkable by their (1) high photosensitivity (2) great latitude in tailoring of film properties, (3) high thermal stability and (4) oxygen insensitivity.

  本发明涉及溶剂可溶聚合材料的制备，这种材料在受到放 射光、X 射线或电子束照射后会变得不溶于溶剂。 这种聚合物是线性嵌段共聚物，由两部分组成：形成连续相的软段和形成分散相的刚性可结晶光活性段。刚性段可选自聚氨酯、聚酯、聚酰胺和聚脲，它们的重复单元中含有二乙炔基团。软段是低分子量的橡胶聚合物，可选自聚醚、聚酯、聚二烯和聚硅氧烷等组。 生产出的聚合物可广泛应用于涂料和制图领域。更具体地说，本发明涉及负片光刻胶，其显著特点是：(1) 高光敏性；(2) 在定制薄膜特性方面有很大的自由度；(3) 高热稳定性；(4) 对氧不敏感。
• Dentifrice compositions having improved anticalculus properties
  申请人：Colgate-Palmolive Company

  公开号：EP0712624A2

  公开（公告）日：1996-05-22

  A storage stable oral composition which is effective against calculus which contains an orally acceptable vehicle having incorporated therein an effective anticalculus combination of about 0.5 to about 2% by weight of a water soluble pyrophosphate salt and about 0.5 to about 3% by weight of a water soluble polyphosphate salt. The presence in the composition of polyvalent metal compounds and fluoride compounds do not affect the stability of the composition as well as reactive ingredients such as peroxide and bicarbonate compounds.

  一种贮存稳定的口服组合物，可有效防治牙结石，该组合物含有一种口服可接受载体，其中掺入了有效的抗牙结石组合物，即约 0.5%至约 2%（按重量计）的水溶性焦磷酸盐和约 0.5%至约 3%（按重量计）的水溶性聚磷酸盐。组合物中多价金属化合物和氟化物化合物以及过氧化物和碳酸氢盐化合物等活性成分的存在不会影响组合物的稳定性。