组氨醛 | 23784-15-8

• 分子结构分类: 有机化合物 - 有机氮化合物
• 中文名称: 组氨醛
• 中文别名: (2S)-2-氨基-3-(1H-咪唑-5-基)丙醛
• 英文名称: Histidinal
• 英文别名: (2S)-2-amino-3-(1H-imidazol-5-yl)propanal
• CAS: 23784-15-8
• 化学式: C₆H₉N₃O
• 分子量: 139.16
• InChiKey: VYOIELONWKIZJS-YFKPBYRVSA-N

物化性质

• 沸点：
  350.2±32.0 °C(Predicted)
• 密度：
  1.246±0.06 g/cm3(Predicted)
• 物理描述：
  Solid

计算性质

• 辛醇/水分配系数(LogP)：
  -1
• 重原子数：
  10
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  71.8
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• METHOD FOR THE VACCINATION AGAINST HIV
  申请人：BIONOR IMMUNO AS

  公开号：US20170000876A1

  公开（公告）日：2017-01-05

  The present invention relates to novel compositions of active agents and methods for the treatment of HIV infection and AIDS. In particular, the present invention relates to novel methods to select HIV infected patients with improved responses to HIV-specific vaccine peptides.

  本发明涉及新型活性剂组合物和治疗HIV感染和艾滋病的方法。具体而言，本发明涉及用于选择对HIV特异性疫苗肽具有改善反应的HIV感染患者的新方法。
• Active agent delivery systems and methods for protecting and administering active agents
  申请人：Mickle Travis

  公开号：US20070232529A1

  公开（公告）日：2007-10-04

  The present invention relates to active agent delivery systems and more specifically to compositions that comprise amino acids, as single amino acids or peptides, covalently attached to active agents and methods for administering conjugated active agent compositions.

  本发明涉及活性物质输送系统，更具体地涉及包含氨基酸（作为单个氨基酸或肽）与活性物质共价连接的组合物以及用于给予共轭活性物质组合物的方法。
• Benzoxazepine compounds, their production and use
  申请人：Yukimasa Hidefumi

  公开号：US20080153801A1

  公开（公告）日：2008-06-26

  This invention provides new benzoxazepine compounds represented by the formula: [wherein R stands for a lower alkyl group optionally substituted with a hydroxyl group, X stands for an optionally substituted carbamoyl group or an optionally substituted heterocyclic group having a deprotonatable hydrogen atom, R 1 stands for a lower alkyl group and W stands for a halogen atom] having activities of lowering chlesterol-level and lowering trigluceride-level, and being useful for prophylaxis and therapy of hyperlipidemia.

  这项发明提供了新的苯并噁唑化合物，其化学式为：[其中R代表可选地取代羟基的低碳基，X代表可选地取代的氨基甲酰基或具有可去质子氢原子的可选地取代的杂环基，R1代表低碳基，W代表卤素原子]，具有降低胆固醇水平和三酰甘油水平的活性，并可用于预防和治疗高脂血症。
• METHODS FOR THE SYNTHESIS OF TWO OR MORE DICARBA BRIDGES IN ORGANIC COMPOUNDS
  申请人：Syngene Limited

  公开号：US20130123463A1

  公开（公告）日：2013-05-16

  Described herein are methods for forming two or more dicarba bridges, as well as new compounds containing dicarba bridges.

  本文描述了形成两个或更多二碳桥的方法，以及包含二碳桥的新化合物。
• METHODS FOR THE SYNTHESIS OF DICARBA BRIDGES IN ORGANIC COMPOUNDS
  申请人：SYNGENE LIMITED

  公开号：US20150315243A1

  公开（公告）日：2015-11-05

  The present invention relates to methods for forming dicarba bridges in organic compounds. This involves the use of a pair of complementary metathesisable groups on the organic compound, and subjecting the compound to cross-metathesis under microwave radiation conditions. In an alternative, the compounds contain a turn-inducing group between the pair of cross-metathesisable groups to facilitate the cross-metathesis.

  本发明涉及在有机化合物中形成二碳桥的方法。这涉及在有机化合物上使用一对互补的可交换基团，并在微波辐射条件下使化合物经受交叉重合反应。另一种选择是，在可交叉重合基团对之间包含一个转向诱导基团，以促进交叉重合反应。