Decyl-<2-hydroxy-1,1-bis-hydroxymethyl-ethyl>-amin | 18372-47-9

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: Decyl-<2-hydroxy-1,1-bis-hydroxymethyl-ethyl>-amin
• 英文别名: 2-(decylamino)-2-(hydroxymethyl)propane-1,3-diol；2-(Decylamino)-2-(hydroxymethyl)propane-1,3-diol hydrochloride
• CAS: 18372-47-9
• 化学式: C₁₄H₃₁NO₃
• 分子量: 261.405
• InChiKey: ZVJANWOVRRASPU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  18
• 可旋转键数：
  13
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  72.7
• 氢给体数：
  4
• 氢受体数：
  4

文献信息

• [EN] NOVEL SYNTHETIC ANALOGS OF SPHINGOLIPIDS<br/>[FR] NOUVEAUX ANALOGUES SYNTHÉTIQUES DE SPHINGOLIPIDES
  申请人：YISSUM RES DEV CO

  公开号：WO2009060457A1

  公开（公告）日：2009-05-14

  The present invention provides new ceramide analogs indicated as the compounds of formula (II). These novel analogs exhibit a significant anti cancerous effect and are therefore provided as a pharmaceutical composition for treating cell proliferative diseases, neurodegenerative disorders, metabolism-associated conditions, infectious diseases, and immune-related disorders. The invention further provides combined compositions and kits combining the novel ceramide analogs of formula (II) with an additional therapeutic agent.

  本发明提供了新的鞘氨醇类似物，表示为式（II）的化合物。这些新颖的类似物表现出显著的抗癌效果，因此被作为治疗细胞增殖性疾病、神经退行性疾病、与代谢相关的疾病、传染病和免疫相关疾病的药物组合物。该发明还提供了将式（II）的新颖鞘氨醇类似物与额外治疗剂结合的联合组合物和配套工具。
• NOVEL SYNTHETIC ANALOGS OF SPHINGOLIPIDS
  申请人：HADASIT MEDICAL RESEARCH SERVICES & DEVELOPMENT LIMITED

  公开号：US20150073003A1

  公开（公告）日：2015-03-12

  The present invention provides new ceramide analogs indicated as the compounds of formula (II). These novel analogs exhibit a significant anti cancerous effect and are therefore provided as a pharmaceutical composition for treating cell proliferative diseases, neurodegenerative disorders, metabolism-associated conditions, infectious diseases, and immune-related disorders. The invention further provides combined compositions and kits combining the novel ceramide analogs of formula (II) with an additional therapeutic agent.

  本发明提供了新的神经酰胺类似物，其被指定为公式（II）化合物。这些新颖的类似物表现出显著的抗癌作用，因此作为治疗细胞增殖性疾病、神经退行性疾病、与代谢相关的疾病、感染性疾病和免疫相关疾病的药物组合物而提供。本发明还提供了将公式（II）的新的神经酰胺类似物与其他治疗剂组合的组合物和套件。
• Deodorant compositions
  申请人：Kao Corporation

  公开号：EP1787689A1

  公开（公告）日：2007-05-23

  The present invention relates to a deodorant composition including (a) a polyhydroxyamine compound having a specific structure and/or a salt thereof, and (b) a penetrant including at least one substance selected from the group consisting of (b1) a nonionic surfactant having a specific structure, (b2) a surfactant having a residue of a monosaccharide, etc., (b3) a nonionic organic solvent having a log P value of from 0 to 4; and (b4) an amine oxide type or carbobetaine type amphoteric surfactant; as well as a deodorizing method using the deodorant composition. The deodorant composition of the present invention is capable of reducing or eliminating a composite odor derived from sweat smell and aldehydes, readily producing a water-based deodorant, and is safe for human use.

  本发明涉及一种除臭剂组合物，包括(a)具有特定结构的多羟胺化合物和/或其盐，和(b)渗透剂，包括至少一种选自以下组别的物质：(b1)具有特定结构的非离子表面活性剂，(b2)具有单糖残基的表面活性剂等、(b3) 对数 P 值为 0 至 4 的非离子有机溶剂；以及 (b4) 氧化胺型或碳甜菜碱型两性表面活性剂；以及使用该除臭组合物的除臭方法。本发明的除臭剂组合物能够减轻或消除由汗味和醛类产生的复合气味，易于生产水基除臭剂，并且对人体使用安全。
• ANTIFUNGAL COMPOSITION
  申请人：Kao Corporation

  公开号：EP2206430A1

  公开（公告）日：2010-07-14

  The present invention provides the antifungal composition, containing the compound (a) selected from specific quaternary ammonium salts and specific amine oxides and the sequestering agent (b) having a calcium-chelating constant of 4 to 12 at a mass ratio (a)/(b) of 0.01 to 10.

  本发明提供的抗真菌组合物含有选自特定季铵盐和特定氧化胺的化合物（a）以及螯合钙常数为 4 至 12 的螯合剂（b），其质量比（a）/（b）为 0.01 至 10。
• DEODORIZING METHOD AND DEODORIZING ARTICLE
  申请人：Kao Corporation

  公开号：EP3851128A1

  公开（公告）日：2021-07-21

  Provided is a method for deodorizing a breast cancerous skin ulcer disease odor emitted from a breast cancerous skin ulcer site and including mainly acetoin using a deodorant article including a sheet-like covering. The sheet-like covering contains a polyhydroxyamine compound or a salt thereof and porous particles, a wound contact surface in the sheet-like covering includes an air-through nonwoven fabric, and the sheet-like covering has a value of a ratio of an area S (cm2) to a thickness T (cm), S/T, of 300 or more and 3000 or less. The polyhydroxyamine compound or the salt thereof is suitably tris(hydroxymethyl)aminomethane.

  本发明提供了一种使用包括片状覆盖物的除臭物品对乳腺癌皮肤溃疡部位散发的乳腺癌皮肤溃疡疾病气味进行除臭的方法，主要包括乙酰丙酮。片状覆盖物含有聚羟胺化合物或其盐和多孔颗粒，片状覆盖物中的伤口接触面包括透气无纺布，片状覆盖物的面积 S（cm2）与厚度 T（cm）的比值 S/T 为 300 或以上、3000 或以下。聚羟胺化合物或其盐最好是三(羟甲基)氨基甲烷。