3β-(9'-xantenecarbonyloxy)-nortropane | 1019982-89-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并吡喃
• 英文名称: 3β-(9'-xantenecarbonyloxy)-nortropane
• CAS: 1019982-89-8
• 化学式: C₂₁H₂₁NO₃
• 分子量: 335.403
• InChiKey: AMSBJJAQPCGPNP-QDMKHBRRSA-N

反应信息

• 作为产物：
  描述：

  在 溶剂黄146 、 锌 作用下， 以 水 为溶剂， 反应 2.0h， 以2.85 g的产率得到3β-(9'-xantenecarbonyloxy)-nortropane
  参考文献：
  名称：

  Synthesis of (nor)tropeine (di)esters and allosteric modulation of glycine receptor binding

  摘要：

  (Hetero) aromatic mono- and diesters of tropine and nortropine were prepared. Modulation of [H-3] strychnine binding to glycine receptors of rat spinal cord was examined with a ternary allosteric model. The esters displaced [H-3] strychnine binding with nano- or micromolar potencies and strong negative cooperativity. Coplanarity and distance of the ester moieties of diesters affected the binding affinity being nanomolar for isophthaloyl-bistropane and nortropeines. Nortropisetron had the highest affinity (K-A similar to 10 nM). Two esters displayed negative cooperativity with glycine in displacement, while three esters of low-affinity and nor-tropisetron exerted positive cooperativity with glycine. (c) 2007 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2007.10.097