2-(2,4-dichlorophenoxy)-N-(6-fluoro-1,2,3,4-tetrahydronaphthalen-1-yl)propanamide | 1418283-28-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 四氢化萘
• 英文名称: 2-(2,4-dichlorophenoxy)-N-(6-fluoro-1,2,3,4-tetrahydronaphthalen-1-yl)propanamide
• CAS: 1418283-28-9
• 化学式: C₁₉H₁₈Cl₂FNO₂
• 分子量: 382.262
• InChiKey: IWNKPHRXGIRTSL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.3
• 重原子数：
  25
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  38.3
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• INHIBITORS OF BACTERIAL TYPE III SECRETION SYSTEM
  申请人：Moir Donald T.

  公开号：US20140219995A1

  公开（公告）日：2014-08-07

  Organic compounds showing the ability to inhibit effector toxin secretion or translocation mediated by bacterial type III secretion systems are disclosed. The disclosed type III secretion system inhibitor compounds are useful for combating infections by Gram-negative bacteria such as Salmonella spp., Shigella flexneri, Pseudomonas spp., Yersinia spp., enteropathogenic and enteroinvasive Escherichia coli , and Chlamydia spp. having such type III secretion systems.

  本发明揭示了一种有机化合物，其具有抑制由细菌III型分泌系统介导的效应毒素分泌或转位的能力。揭示的III型分泌系统抑制剂化合物对于对抗革兰氏阴性菌的感染非常有用，例如沙门氏菌属，弯曲杆菌，假单胞菌属，耶尔森菌属，肠致病性和肠侵袭性大肠杆菌以及具有此类III型分泌系统的沙眼衣原体属。
• [EN] INHIBITORS OF BACTERIAL TYPE III SECRETION SYSTEM<br/>[FR] INHIBITEURS DU SYSTÈME DE SÉCRÉTION BACTÉRIENNE DE TYPE III
  申请人：MICROBIOTIX INC

  公开号：WO2013010089A2

  公开（公告）日：2013-01-17

  Organic compounds showing the ability to inhibit effector toxin secretion or translocation mediated by bacterial type III secretion systems are disclosed. The disclosed type III secretion system inhibitor compounds are useful for combating infections by Gram-negative bacteria such as Salmonella spp., Shigella flexneri, Pseudomonas spp., Yersinia spp., enteropathogenic and enteroinvasive Escherichia coli, and Chlamydia spp. having such type III secretion systems.