氟培龙 | 3841-11-0

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 中文名称: 氟培龙
• 英文名称: (8S,9R,10S,11S,13S,14S,17R)-9-fluoro-11,17-dihydroxy-17-(2-hydroxypropanoyl)-10,13-dimethyl-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-3-one
• CAS: 3841-11-0
• 化学式: C₂₂H₂₉FO₅
• 分子量: 392.5
• InChiKey: SLVCCRYLKTYUQP-IAIMTWSWSA-N

物化性质

• 沸点：
  569.5±50.0 °C(Predicted)
• 密度：
  1.32±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  28
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.73
• 拓扑面积：
  94.8
• 氢给体数：
  3
• 氢受体数：
  6

文献信息

• FORMULATIONS AND DOSES OF PEGYLATED URICASE
  申请人：Selecta Biosciences, Inc.

  公开号：EP3980784A1

  公开（公告）日：2022-04-13
• METHODS AND COMPOSITIONS RELATED TO COMBINED TREATMENT WITH ANTIINFLAMMATORIES AND SYNTHETIC NANOCARRIERS COMPRISING AN IMMUNOSUPPRESSANT
  申请人：Johnston Lloyd

  公开号：US20180289776A1

  公开（公告）日：2018-10-11

  Provided herein are methods and compositions, such as kits, related to compositions comprising synthetic nanocarriers comprising an immunosuppressant and compositions comprising an uricase and a composition comprising an anti-inflammatory therapeutic. Also provided herein are methods and compositions for the treatment of subjects in need of administration or treatment with the uricase.
• METHOD TO REPRODUCE CIRCADIAN RHYTHMS ON A MICROFLUIDIC CHIP
  申请人：Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.

  公开号：US20200318077A1

  公开（公告）日：2020-10-08

  Provided are in-vitro methods and devices for sustaining a synchronized circadian rhythm in cells of a cell culture by exposing the cells to a continuous flow of medium and to at least two stimuli provided in an oscillating manner with a periodicity of 24±4 hours, wherein a first stimulus and a second stimulus of said at least two stimuli are distinct, wherein said first stimulus is provided in a first time period and reaches a first peak in a first peak time period, and wherein a second stimulus is provided in a second time period and reaches a second peak in a second peak time period, and wherein an interval between end of time period of said first peak and beginning of said time period of said second peak is at least about 2 hours.
• METHODS AND COMPOSITIONS FOR ATTENUATED ANTI-VIRAL TRANSFER VECTOR IMMUNE RESPONSE
  申请人：Selecta Biosciences, Inc.

  公开号：US20200390718A1

  公开（公告）日：2020-12-17

  Provided herein are methods and related compositions or kits for administering viral transfer vectors in combination with synthetic nanocarriers comprising an immunosuppressant and a corticosteroid.
• [EN] METHODS AND COMPOSITIONS FOR ATTENUATED ANTI-VIRAL TRANSFER VECTOR IMMUNE RESPONSE<br/>[FR] PROCÉDÉS ET COMPOSITIONS PERMETTANT D'ATTÉNUER LES RÉPONSES IMMUNITAIRES ANTI-VIRALES AUX VECTEURS DE TRANSFERT
  申请人：SELECTA BIOSCIENCES INC

  公开号：WO2020243261A1

  公开（公告）日：2020-12-03

  Provided herein are methods and related compositions or kits for administering viral transfer vectors in combination with synthetic nanocarriers comprising an immunosuppressant and a corticosteroid.