bis(1-isoquinolyl)ketone | 102047-50-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异喹啉及其衍生物
• 英文名称: bis(1-isoquinolyl)ketone
• 英文别名: 1,1'-Di-isochinolyl-keton；di-isoquinolin-1-yl-methanone；di-[1]isoquinolyl ketone；Di-[1]isochinolyl-keton；Isoquinolyl ketone；di(isoquinolin-1-yl)methanone
• CAS: 102047-50-7
• 化学式: C₁₉H₁₂N₂O
• 分子量: 284.317
• InChiKey: WBVYLJDKQFBTGP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.3
• 重原子数：
  22
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  42.8
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  1-溴异喹啉 在 乙醚 作用下， 生成 bis(1-isoquinolyl)ketone
  参考文献：
  名称：

  Notes - Carbonation of Lithium Derivatives of Certain Quinolines and Isoquinolines

  摘要：

  DOI：

  10.1021/jo01356a605

文献信息

• Studies on Organometallic Compounds. VII. Reaction of Di-tert-butyl Dicarbonate with .ALPHA.-Trialkylstannyl Derivatives of Pyridine, Quinoline, and Isoquinoline.
  作者：Yutaka YAMAMOTO、Hidekazu OUCHI、Takuo TANAKA

  DOI：10.1248/cpb.43.916

  日期：——

  Di-tert-butyl dicarbonate was found to be effective for direct introduction of a tert-butoxycarbonyl group at the α-position of the pyridine nucleus via the trialkylstannyl group; reaction of α-trialkylstannyl derivatives of pyridine, quinoline, and isoquinoline with di-tert-butyl dicarbonate gave the corresponding α-tert-butoxycarbonyl derivatives in good yields, althrough small amounts of a variety of by-products were formed except in the case of pyridine.

  研究发现，二叔丁基二碳酸酯可有效通过三烷基锡基团直接在吡啶核的α位引入叔丁氧羰基。反应中，吡啶、喹啉和异喹啉的α-三烷基锡衍生物与二叔丁基二碳酸酯反应，以良好产率生成相应的α-叔丁氧羰基衍生物，但在吡啶的情况下，除少量多种副产物生成外。
• Fungal cell wall synthesis gene
  申请人：Tsukahara Kappei

  公开号：US20060234283A1

  公开（公告）日：2006-10-19

  A reporter system reflecting the transport process that transports GPI-anchored proteins to the cell wall was constructed and compounds inhibiting this process were discovered. Further, genes conferring resistance to the above compounds were identified and methods of screening for compounds that inhibit the activity of the proteins encoded by these genes were developed. Therefore, through the novel compounds, the present invention showed that antifungal agents having a novel mechanism, i.e. inhibiting the process that transports GPI-anchored proteins to the cell wall, could be achieved.

  构建了一个反映运输GPI锚定蛋白到细胞壁的运输过程的记者系统，并发现了抑制这一过程的化合物。此外，鉴定了赋予对上述化合物抗性的基因，并开发了筛选抑制这些基因编码的蛋白质活性的化合物的方法。因此，通过这些新化合物，本发明表明可以实现具有新机制的抗真菌剂，即抑制运输GPI锚定蛋白到细胞壁的过程。
• FUNGAL CELL WALL SYNTHESIS GENE
  申请人：Tsukahara Kappei

  公开号：US20080261272A1

  公开（公告）日：2008-10-23

  A reporter system reflecting the transport process that transports GPI-anchored proteins to the cell wall was constructed and compounds inhibiting this process were discovered. Further, genes conferring resistance to the above compounds were identified and methods of screening for compounds that inhibit the activity of the proteins encoded by these genes were developed. Therefore, through the novel compounds, the present invention showed that antifungal agents having a novel mechanism, i.e. inhibiting the process that transports GPI-anchored proteins to the cell wall, could be achieved.

  建立了一个反映将GPI锚定蛋白转运到细胞壁的运输过程的记者系统，并发现了抑制该过程的化合物。此外，还鉴定了赋予抵抗上述化合物的基因，并开发了筛选抑制这些基因编码蛋白活性的化合物的方法。因此，通过这些新型化合物，本发明展示了可以实现具有新型机制的抗真菌剂，即抑制将GPI锚定蛋白转运到细胞壁的过程。
• POLYMER COMPOUND AND COMPOSITION CONTAINING THE SAME
  申请人：Mikami Satoshi

  公开号：US20100033086A1

  公开（公告）日：2010-02-11

  A polymer compound comprising as repeating units an optionally substituted fluorenediyl group and a phenylene group having one or more substituents, and comprising a repeating unit of the following formula (1) and/or a group of the following formula (2): (in the formula (1), Ar 1 and Ar 2 represent an arylene group or di-valent aromatic heterocyclic group, and Ar 1 and may be the same or different.) (in the formula (2), Ar 1 represents the same meaning as described above. Ar 3 represents an aryl group or mono-valent aromatic heterocyclic group.).

  一种聚合物化合物，其重复单元包括一个可选取代的芴基基团和一个具有一个或多个取代基的苯基团，并包括以下式(1)的重复单元和/或以下式(2)的基团： （在式（1）中，Ar1和Ar2表示芳烃基团或双价芳香杂环基团，Ar1和Ar2可以相同或不同。） （在式（2）中，Ar1表示与上述相同的含义。Ar3表示芳基团或单价芳香杂环基团。）
• US7375204B2
  申请人：——

  公开号：US7375204B2

  公开（公告）日：2008-05-20