N'-{1-[4-((4aR,10bS)-9-ethoxy-8-methoxy-2-methyl-1,2,3,4,4a,10b-hexahydrobenzo[c][1,6]naphthyridin-6-yl)-phenyl]-methanoyl}-N,N-bis-(2-methoxy-ethyl)-guanidine | 667464-38-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: N'-{1-[4-((4aR,10bS)-9-ethoxy-8-methoxy-2-methyl-1,2,3,4,4a,10b-hexahydrobenzo[c][1,6]naphthyridin-6-yl)-phenyl]-methanoyl}-N,N-bis-(2-methoxy-ethyl)-guanidine
• 英文别名: {1-[4-((4aR,10bS)-9-Ethoxy-8-methoxy-2-methyl-1,2,3,4,4a,10b-hexahydro-benzo[c][1,6]naphthyridin-6-yl)-phenyl]-methanoyl}-N,N-bis-(2-methoxy-ethyl)-guanidine；4-[(4aR,10bS)-9-ethoxy-8-methoxy-2-methyl-3,4,4a,10b-tetrahydro-1H-benzo[c][1,6]naphthyridin-6-yl]-N-[N,N-bis(2-methoxyethyl)carbamimidoyl]benzamide
• CAS: 667464-38-2
• 化学式: C₃₀H₄₁N₅O₅
• 分子量: 551.686
• InChiKey: YNKBHOPWFHOJGV-JWQCQUIFSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  40
• 可旋转键数：
  12
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  111
• 氢给体数：
  1
• 氢受体数：
  7

文献信息

• NOVEL BENZONAPHTHYRIDINES
  申请人：ALTANA Pharma AG

  公开号：EP1581533A2

  公开（公告）日：2005-10-05
• [EN] NOVEL BENZONAPHTHYRIDINES<br/>[FR] NOUVELLES BENZONAPHTYRIDINES
  申请人：ALTANA PHARMA AG

  公开号：WO2004018465A2

  公开（公告）日：2004-03-04

  Compounds of a certain formula (1), in which R1, R2, R3, R4 and R5 have the meanings indicated in the description, are novel effective PDE4 or PDE3/4 inhibitors.