ethyl 4'-amino-3,4-dihydro-2H,1'H-spiro[naphthalene-1,2'-pyrimido[1,2-a]benzimidazole]-3'-carboxylate | 1083171-84-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 四氢化萘
• 英文名称: ethyl 4'-amino-3,4-dihydro-2H,1'H-spiro[naphthalene-1,2'-pyrimido[1,2-a]benzimidazole]-3'-carboxylate
• CAS: 1083171-84-9
• 化学式: C₂₂H₂₂N₄O₂
• 分子量: 374.442
• InChiKey: ICLKCVZQROKHLF-UHFFFAOYSA-N

反应信息

• 作为产物：
  描述：

  2-氨基苯并咪唑 、 氰乙酸乙酯 、 3,4-二氢-1(2H)-萘酮 以 水 为溶剂， 以78%的产率得到ethyl 4'-amino-3,4-dihydro-2H,1'H-spiro[naphthalene-1,2'-pyrimido[1,2-a]benzimidazole]-3'-carboxylate
  参考文献：
  名称：

  Versatility of Alternative Reaction Media: Water-Mediated Domino and Green Chemical Synthesis of Pyrimido[1,2-a]benzimidazole Under Nonconventional Conditions

  摘要：

  A convenient and clean water-mediated synthesis of a series of 4-amino-2-aryl-1,2-dihydro pyrimido[1,2-a]benzimidazoles (4) is reported using alternative nonconventional energy sources. The products are obtained in shorter times with excellent yields (78-89%) from the multicomponent reaction of 2-aminobenzimidazole (1), malononitrile/ethylcyanoacetate (2a/b), and carbonyl compounds (3). The reaction is found to be general with respect to the cyclic and acyclic carbonyl compounds. The procedure does not involve the use of any additional reagent/catalyst, produces no waste, and represents a green synthetic protocol with high atom economy.

  DOI：

  10.1080/00397910802164732