7-n-decyl-1-tetralone | 95576-35-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 四氢化萘
• 英文名称: 7-n-decyl-1-tetralone
• 英文别名: 7-Decyl-3,4-dihydronaphthalen-1(2H)-one；7-decyl-3,4-dihydro-2H-naphthalen-1-one
• CAS: 95576-35-5
• 化学式: C₂₀H₃₀O
• 分子量: 286.458
• InChiKey: PSRMZKVKPVLDIJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.2
• 重原子数：
  21
• 可旋转键数：
  9
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.65
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  7-n-decyl-1-tetralone 、 甲酸乙酯 生成 (2E)-7-decyl-2-(hydroxymethylidene)-3,4-dihydronaphthalen-1-one
  参考文献：
  名称：

  YIP, K. F.;CHARLTON, S. C.

  摘要：

  DOI：
• 作为产物：
  描述：

  4-(4-Decylphenyl)butanoic acid 生成 7-n-decyl-1-tetralone
  参考文献：
  名称：

  YIP, K. F.;CHARLTON, S. C.

  摘要：

  DOI：

文献信息

• Compound useful in detecting ions and method of preparing it
  申请人：Miles Laboratories, Inc.

  公开号：US04552697A1

  公开（公告）日：1985-11-12

  A novel compound is disclosed having the structure ##STR1## in which R is H or lower alkyl, R* is intermediate alkyl, and X is halogen or pseudohalogen. Also disclosed is a method for preparing the compound, the method including the steps of reacting (intermediate alkyl)benzene (I) with succinic anhydride to form (intermediate alkyl)-benzoylpropionic acid (II), successively reducing and dehydrating (II) to form 7-(intermediate alkyl)-1-tetralone (III), alkylating (III) to form 2-hydroxy(lower alkylidene)-7-(intermediate alkyl)-1-tetralone (IV), acrylating (IV) to form 2-acyloxy(lower alkylidene)-7-(intermediate alkyl)-1-tetralone (V), reacting (V) in the presence of an cycloalkene to form 7(intermediate alkyl)-2-(lower alkyl)-1-naphthol (VI), reacting (VI) with a 2,6-dihaloquinone-4-haloimide to form the compound (I), and isolating it.

  揭示了一种具有结构##STR1##的新化合物，其中R为H或较低的烷基，R*为中间烷基，X为卤素或伪卤素。还公开了一种制备该化合物的方法，该方法包括以下步骤：将(中间烷基)苯(I)与琥珀酸酐反应以形成(中间烷基)-苯甲酰丙酸(II)，依次还原和脱水(II)以形成7-(中间烷基)-1-四氢萘酮(III)，烷基化(III)以形成2-羟基(较低烷基亚基)-7-(中间烷基)-1-四氢萘酮(IV)，丙烯化(IV)以形成2-酰氧基(较低烷基亚基)-7-(中间烷基)-1-四氢萘酮(V)，在环烯烃存在下将(V)与环烯烃反应以形成7-(中间烷基)-2-(较低烷基)-1-萘酚(VI)，将(VI)与2,6-二卤喹喔酮-4-卤亚胺反应以形成该化合物(I)，并将其分离。
• Unified test means for ion determination
  申请人：Miles Laboratories, Inc.

  公开号：US04645744A1

  公开（公告）日：1987-02-24

  A test means, test device and method for use for determining the presence of an ion in a test sample are disclosed. The test means comprises a substantially nonpolar, nonporous carrier matrix incorporated with an ionophore capable of forming a complex with the specific ion and reporter substance capable of interacting with the complex of ionophore and ion to produce a detectable response. The test means disclosed is particularly useful for serum potassium determinations. The test means forms the reagent layer in a multilayer format particularly suited to whole blood electrolyte determinations.

  本发明公开了一种用于确定检测样品中离子存在的测试手段、测试设备和使用方法。测试手段包括一个基本上非极性、非多孔载体基质，该基质中混合有能够与特定离子形成复合物的离子载体和能够与离子载体和离子的复合物相互作用以产生可检测响应的报告物质。本发明公开的测试手段特别适用于血清钾测定。该测试手段以多层格式形成试剂层，特别适用于全血电解质测定。
• Substituted indonaphthols used in detecting ions
  申请人：MILES INC.

  公开号：EP0128317A2

  公开（公告）日：1984-12-19

  A novel compound is disclosed having the structure in which R is H or lower alkyl, R* is intermediate alkyl, and X is halogen or pseudohalogen. Also disclosed is a method for preparing the compound, the method including the steps of reacting (intermediate alkyl)benzene (I) with succinic anhydride to form (intermediate alkyl)-benzoylpropionic acid (II), successively reducing and dehydrating (II) to form 7-(intermediate alkyl)-1-tetralone (III), alkylating (III) to form 2-hydroxy(lower alkylidene)-7-(intermediate alkyl)-1-tetralone (IV), acrylating (IV) to form 2-acyloxy(lower alkylidene)-7-(intermediate alkyl)-1-tetralone (V), reacting (V) in the presence of an cycloalkene to form 7(intermediate alkyl)-2-(lower alkyl)-1-naphthol (VI), reacting (VI) with a 2,6-dihaloquinone-4-haloimide to form the compound (I), and isolating it.

  公开了一种新型化合物，其结构如下 其中 R 为 H 或低级烷基，R* 为中间烷基，X 为卤素或假卤素。还公开了一种制备该化合物的方法，该方法包括以下步骤：使（中间烷基）苯（I）与丁二酸酐反应生成（中间烷基）-苯甲酰丙酸（II），连续还原和脱水（II）生成 7-（中间烷基）-1-四氢萘酮（III）、烷基化 (III) 形成 2-羟基（亚低级烷基）-7-（中间烷基）-1-四氢萘酮 (IV)，丙烯酰化 (IV) 形成 2-乙酰氧基（亚低级烷基）-7-（中间烷基）-1-四氢萘酮 (V)、使（V）与环烷烃反应生成 7-(中间烷基)-2-(低级烷基)-1-萘酚（VI），使（VI）与 2,6-二卤醌-4-卤酰亚胺反应生成化合物（I），并将其分离。
• Ion test means having a hydrophilic carrier matrix
  申请人：MILES INC.

  公开号：EP0125554A2

  公开（公告）日：1984-11-21

  A test means for determining the presence of an ion in an aqueous test sample is disclosed, as well as a test device incorporating the test means, a method for preparing it and a method for using it. The test means comprises a hydrophilic carrier matrix incorporated with finely divided globules of a hydrophobic vehicle. The hydrophobic vehicle contains an ionophore capable of forming a complex with the ion, and a reporter substance capable of interacting with the complex of ionophore and ion to produce a detectable response. The test device comprises an elongated support member having an upper substantially flat face, the test means being affixed to the flat face of the support member. The method for preparing the device comprises forming a first mixture of water and a hydrophilic polymer, forming a second mixture of a hydrophobic vehicle, an ionophore capable of forming a complex with the ion, and a reporter substance capable of interacting with the complex of the ionophore and ion to produce a detectable response, combining the first and second mixtures to produce a stable emulsion of finely divided globules of the second mixture in the first mixture, coating the emulsion onto an elongated support member having an upper, substantially flat face, and evaporating the water from the emulsion to product a hydrophilic carrier matrix incorporated with finely divided globules of the second mixture, the matrix being thereby affixed to the flat face of the support member. The method for using the test means or device comprises contacting it with the test sample and observing a detectable response.

  本发明公开了一种用于确定水性测试样品中是否存在某种离子的测试手段，以及一种包含该测试手段的测试装置、一种制备方法和一种使用方法。测试装置由亲水性载体基质和细小的疏水性载体球组成。疏水性载体含有能与离子形成复合物的离子疏水剂，以及能与离子疏水剂和离子的复合物相互作用以产生可检测反应的报告物质。 测试装置包括一个细长的支撑件，该支撑件的上部基本上是平的，测试装置被固定在支撑件的平面上。 制备该装置的方法包括：形成水和亲水性聚合物的第一种混合物；形成疏水性载体、能与离子形成络合物的发离子体以及能与发离子体和离子的络合物相互作用以产生可检测反应的报告物质的第二种混合物、将第一混合物和第二混合物混合以产生稳定的乳液，乳液中含有第一混合物中第二混合物的细小颗粒，将乳液涂覆在具有上部基本平坦表面的细长支撑件上，蒸发乳液中的水分以产生亲水性载体基质，基质中含有第二混合物的细小颗粒，基质因此被粘附在支撑件的平坦表面上。 使用测试工具或装置的方法包括将其与测试样品接触并观察可检测到的反应。
• Nuhn; Herrmann; Radman, Pharmazie, 1999, vol. 54, # 2, p. 93 - 98
  作者：Nuhn、Herrmann、Radman

  DOI：——

  日期：——