[Ru(4,7-diphenyl-1,10-phenanthroline)2(dipyrido[3,2-a:2′,3′-c]phenazine)]2+ | 132045-65-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: [Ru(4,7-diphenyl-1,10-phenanthroline)2(dipyrido[3,2-a:2′,3′-c]phenazine)]2+
• 英文别名: ruthenium(II) bis(4,7-diphenyl-1,10-phenathroline)dipyrido[3,2-a:2',3'-c]phenazine；[Ru(4,7-diphenyl-1,10-phenanthroline)₂(dipyrido[3,2-a:2′,3′-c]phenazine)]²⁺；[Ru(DIP)₂(dppz)]²⁺；Ru(DIP)2(dipyridophenazine)(2+)；Ru(DIP)2dppz(2+)
• CAS: 132045-65-9
• 化学式: C₆₆H₄₂N₈Ru
• 分子量: 1048.18
• InChiKey: PPGIRVDJHZAMKA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
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• 可旋转键数：
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• 环数：
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• sp3杂化的碳原子比例：
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• 拓扑面积：
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• 氢给体数：
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• 氢受体数：
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反应信息

• 作为产物：
  描述：

  二吡啶并[3,2-a:2',3'-c]吩嗪 、 Ru(4,7-diphenyl-1,10-phenanthroline)₂Cl₂ 以 乙醇 、 水 为溶剂， 生成 [Ru(4,7-diphenyl-1,10-phenanthroline)2(dipyrido[3,2-a:2′,3′-c]phenazine)]2+
  参考文献：
  名称：

  Methods to Explore Cellular Uptake of Ruthenium Complexes

  摘要：

  The cellular uptake of a series of dipyridophenazine (dppz) complexes of Ru(II) was examined by flow cytometry. The complexes, owing to their facile synthesis, stability, and luminescence, provide a route to compare and contrast systematically factors governing cellular entry. Substituting the ancillary ligands in the dppz complexes of Ru(II) permits variation in the overall complex charge, size, and hydrophobicity. In HeLa cells, cellular uptake appears to be facilitated by the lipophilic 4,7-diphenyl-1,10-phenanthroline (DIP) ligand. Despite the large size of Ru(DIP)2dppz2+ (20 Å diameter), this complex is readily transported inside the cell compared to smaller and more hydrophilic complexes such as Ru(bpy)2dppz2+. Accumulation in the cellular interior is confirmed by confocal microscopy.

  DOI：

  10.1021/ja0677564