1,2,4-Trifluoronaphtalin | 2712-62-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 1,2,4-Trifluoronaphtalin
• 英文别名: 1,2,4-Trifluoronaphthalene
• CAS: 2712-62-1
• 化学式: C₁₀H₅F₃
• 分子量: 182.145
• InChiKey: UWQJIHUZHYTMIX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  13
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  1,2,3,4-四氟萘 在 lithium aluminium tetrahydride 作用下， 以 四氢呋喃 为溶剂， 生成 1,2,4-Trifluoronaphtalin
  参考文献：
  名称：

  多环氟芳族化合物。第五部分1,2,3,4-四氟萘的一些反应

  摘要：

  1,2,3,4-四氟萘分别在碳氟化合物和烃环中经历亲核和亲电子取代。用甲醇钠，肼和氢化铝锂处理时，2-氟原子主要被取代。溴化和硝化反应会生成烃环中取代了α和β的化合物的混合物。

  DOI：

  10.1039/j39710000604

文献信息

• SYNTHESIS OF VICINAL DIFLUORO AROMATICS AND INTERMEDIATES THEREOF
  申请人：——

  公开号：US20020099247A1

  公开（公告）日：2002-07-25

  A method of preparing vicinal difluoro aromatic compounds in high yield from hydroxy aromatic compounds and a method of preparing intermediates thereof. The hydroxy aromatic compound can be a mono-, bi- or tricyclic aromatic in which the rings are separate or fused. One or more of the rings can contain heteroatoms, such as oxygen, nitrogen, or sulfur, and can contain one or more substitutions, in addition to the hydroxy substitution.

  从羟基芳香化合物制备高收率的邻二氟芳香化合物的方法以及制备其中间体的方法。羟基芳香化合物可以是一个单环、双环或三环芳香化合物，其中环是分开的或融合的。一个或多个环可以含有杂原子，如氧、氮或硫，并且除了羟基取代外，还可以含有一个或多个取代基。
• Synthesis of vicinal difluoro aromatics and intermediates thereof
  申请人：——

  公开号：US20030149315A1

  公开（公告）日：2003-08-07

  A method of preparing vicinal difluoro aromatic compounds in high yield from hydroxy aromatic compounds using various bases and a method of preparing intermediates thereof. A method for making a vicinal difluoro halogenated aromatic compound including providing a tetrafluoro derivative of a halogen substituted aromatic compound, wherein the tetrafluoro derivative has two fluorine atoms on each of two adjacent carbons and at least one additional halogen substituent; reacting the tetrafluoro derivative with a reducing agent in presence of a base for a reaction time sufficient to form the vicinal difluoro halogenated aromatic compound containing two vicinal fluorine substituents and the at least one additional halogen substituent, wherein the reducing agent is used in a reducing agent effective amount sufficient to retain the at least one additional halogen substituent.

  一种从羟基芳香化合物中使用各种碱制备高产率邻二氟芳香化合物的方法，以及制备其中间体的方法。一种制备邻二氟卤代芳香化合物的方法，包括提供卤代芳香化合物的四氟衍生物，其中四氟衍生物在两个相邻碳上各有两个氟原子和至少一个额外的卤素取代基；将四氟衍生物与还原剂在碱的存在下反应，反应时间足以形成含有两个邻二氟氟取代基和至少一个额外卤素取代基的邻二氟卤代芳香化合物，其中还原剂用于还原剂有效量足以保留至少一个额外卤素取代基。
• PROCESS FOR PREPARATION OF SUBSTITUTED AROMATIC COMPOUND
  申请人：——

  公开号：US20020161227A1

  公开（公告）日：2002-10-31

  A substituted aromatic compound substituted with Q is obtained by reacting a phosphazenium compound represented by formula (1) 1 (in the formula, Q − represents an anion in a form derived by elimination of a proton from an inorganic acid, or an active hydrogen compound having an active hydrogen on an oxygen atom, a nitrogen atom or a sulfur atom; a, b, c and d, each independently, is 0 or 1, but all of them are not 0 simultaneously; and R groups represent the same or different hydrocarbon groups having 1 to 10 carbon atoms, or two Rs on each common nitrogen atom may be bonded together to form a ring structure) with a halogenated aromatic compound having halogen atoms; whereby, at least one halogen atom in the halogenated aromatic compound is substituted with Q (where, Q represents an inorganic group or an organic group in a form derived by elimination of one electron from Q − in formula (1)).

  通过将式（1）1所代表的磷氮化合物与含有卤原子的芳香化合物反应，可以得到一种被Q取代的取代芳香化合物（其中，Q-在公式中代表从无机酸中去除质子或具有氧原子、氮原子或硫原子上的活性氢的活性氢化合物所导出的形式的阴离子；a、b、c和d各自独立地为0或1，但它们不同时为0；R基表示具有1至10个碳原子的相同或不同的碳氢基团，或者在每个共同氮原子上的两个R可能被结合在一起形成环状结构）。因此，至少有一个卤原子被Q取代（其中，Q在公式（1）中代表从Q-中去除一个电子所导出的无机基团或有机基团）。
• PROCESS FOR PRODUCING SUBSTITUTED AROMATIC COMPOUND
  申请人：Mitsui Chemicals, Inc.

  公开号：EP1275630A1

  公开（公告）日：2003-01-15

  A substituted aromatic compound substituted with Q is obtained by reacting a phosphazenium compound represented by formula (1) (in the formula, Q- represents an anion in a form derived by elimination of a proton from an inorganic acid, or an active hydrogen compound having an active hydrogen on an oxygen atom, a nitrogen atom or a sulfur atom; a, b, c and d, each independently, is 0 or 1, but all of them are not 0 simultaneously; and R groups represent the same or different hydrocarbon groups having 1 to 10 carbon atoms, or two Rs on each common nitrogen atom may be bonded together to form a ring structure) with a halogenated aromatic compound having halogen atoms; whereby, at least one halogen atom in the halogenated aromatic compound is substituted with Q (where, Q represents an inorganic group or an organic group in a form derived by elimination of one electron from Q- in formula (1)).

  将式(1)代表的鏻化合物与 Q 取代的取代芳香族化合物反应，可获得取代芳香族化合物 式中 Q- 代表通过从无机酸中消除质子而得到的阴离子，或在氧原子、氮原子或硫原子上具有活泼氢的活泼氢化合物； a、b、c 和 d 各自独立地为 0 或 1，但它们同时都不是 0；以及 R 基团代表具有 1 至 10 个碳原子的相同或不同的烃基，或每个公共氮原子上的两个 R 可键合在一起形成环结构）与具有卤素原子的卤代芳香族化合物；其中，卤代芳香族化合物中的至少一个卤素原子被以下物质取代 Q (其中，Q 代表无机基团或有机基团，其形式是通过消除式（1）中 Q- 的一个电子而得到的）。
• NAPHTHOBISCHALCOGENADIAZOLE DERIVATIVE AND PRODUCTION METHOD THEREFOR
  申请人：Osaka University

  公开号：EP3564245A1

  公开（公告）日：2019-11-06

  In order to provide a naphthobischalcogenadiazole derivative that can be used as an intermediate for producing a naphthobischalcogenadiazole compound into which a fluorine atom has been introduced, the naphthobischalcogenadiazole derivative in accordance with an aspect of the present invention is represented by a formula (I): where each of A1 and A2 is independently an oxygen atom, a sulfur atom, a selenium atom, or a tellurium atom; and each of X1 and X2 is independently a hydrogen atom, a halogen atom, a boronic acid group, a boronic acid ester group, a boronic acid diaminonaphthalene amide group, an N-methyliminodiacetic acid boronate group, a trifluoroborate salt group, or a triolborate salt group.

  为了提供一种萘二异噻二唑衍生物，该衍生物可用作生产引入了氟原子的萘二 异噻二唑化合物的中间体，根据本发明的一个方面，萘二异噻二唑衍生物由式 (I) 表示： 其中A1和A2各自独立地为氧原子、硫原子、硒原子或碲原子；X1和X2各自独立地为氢原子、卤素原子、硼酸基团、硼酸酯基团、硼酸二氨基萘酰胺基团、N-甲基亚氨基二乙酸硼酸盐基团、三氟硼酸盐基团或三硼酸盐基团。