| 622847-83-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• CAS: 622847-83-0
• 化学式: C₁₅H₁₃N₃O₂
• 分子量: 267.287
• InChiKey: VPYLCDTXARRADT-UHFFFAOYSA-N

反应信息

• 作为反应物：
  描述：

  、 2-甲氧基乙胺 以 1,4-二氧六环 为溶剂， 以96%的产率得到(Z)-6-hydroxy-3-(2-methoxyethylamino)-2-(4-oxo-3H-quinazolin-2-yl)hept-2-enenitrile
  参考文献：
  名称：

  Synthesis of 2-(2-hetaryl)-6-hydroxy-3-(R-amino)-2-hexenenitriles

  摘要：

  The reaction of 2-hetaryl-2-(tetrahydrofuran-2-ylidene)acetonitriles and 6-chloro-2-(2-hetarylidene)-3-oxohexanenitriles with amines was studied. It was shown that the reaction of primary aliphatic amines with 6-chloro-2-(2-hetarylidene)-3-oxohexanenitriles takes place through a stage involving the formation of 2-hetaryl-2-(tetrahydrofuran-2-ylidene)acetonitriles followed by opening of the furanylidene fragment of the latter and the formation of 2-(2-hetaryl)-6-hydroxy-3-(R-amino)-2-hexenenitriles.

  DOI：

  10.1007/s10593-013-1208-2
• 作为产物：
  描述：

  6-chloro-3-oxo-2-(4-oxo-1H-quinazolin-2-ylidene)heptanenitrile 在 三乙胺 作用下， 以 1,4-二氧六环 为溶剂， 以89%的产率得到
  参考文献：
  名称：

  Synthesis of 2-hetaryl-2-(tetrahydrofuran-2-ylidene)acetonitriles

  摘要：

  The reaction of azolylacetonitriles with gamma-chlorobutyryl chlorides gave the corresponding 2-(1-R-1,3-dihydro-2H-benzimidazol-2-ylidene)-, 2-(1,3-benzothiazol-2-ylidene)-, and 6-chloro-2-(4-methylthiazol-2-ylidene)-3-oxohexanenitriles. A study of the intramolecular cyclization of 2-(quinazolin-2-ylidene)-3-oxo-6-hexanenitriles and -heptanenitriles has led to the development of an efficient method for the preparation of 2-(quinazolin-2-yl)-2-(tetrahydrofuran-2-ylidene)acetonitriles. The (Z,E)-isomerism of the synthesized 2-hetaryl-2-(tetrahydrofuran-2-ylidene)acetonitriles was studied.

  DOI：

  10.1007/s10593-011-0885-y