ethyl 6-(3-(benzo[b]thiophene-2-carboxamido)phenyl)-1H-indazole-3-carboxylate | 1228450-86-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻吩类
• 英文名称: ethyl 6-(3-(benzo[b]thiophene-2-carboxamido)phenyl)-1H-indazole-3-carboxylate
• 英文别名: ethyl 6-[3-(1-benzothiophene-2-carbonylamino)phenyl]-1H-indazole-3-carboxylate
• CAS: 1228450-86-9
• 化学式: C₂₅H₁₉N₃O₃S
• 分子量: 441.51
• InChiKey: ODUUAEQNZSRVDT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.9
• 重原子数：
  32
• 可旋转键数：
  6
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  112
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• NOVEL INDAZOLE DERIVATIVES OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF AS PROTEIN KINASE INHIBITORS FOR PROLIFERATIVE DISEASES TREATMENT, AND A PHARMACEUTICAL COMPOSITION CONTAINING THE SAME AS AN ACTIVE INGREDIENT
  申请人：Sim Tae Bo

  公开号：US20120130069A1

  公开（公告）日：2012-05-24

  Disclosed are novel indazole derivatives represented by the following Chemical Formula 1 or pharmaceutically acceptable salts, hydrates or solvates thereof, and pharmaceutical compositions for the prevention or treatment of proliferative diseases, containing the same as an active ingredient. Having potent inhibitory effect against protein kinase, such as b-raf, KDR, Fms, Tie2, SAPK2a and Ret, inducing diseases caused by abnormal cell proliferation, the novel indazole derivatives can be used for the prevention or treatment of diseases caused by abnormal cell proliferation.

  本发明揭示了新型吲唑衍生物，其化学式如下所示（Chemical Formula 1），或其药学上可接受的盐、水合物或溶剂化合物，以及包含其作为活性成分的用于预防或治疗增殖性疾病的药物组合物。这些新型吲唑衍生物具有对蛋白激酶（如b-raf、KDR、Fms、Tie2、SAPK2a和Ret）具有强大的抑制作用，诱导由异常细胞增殖引起的疾病，可用于预防或治疗由异常细胞增殖引起的疾病。
• US8754209B2
  申请人：——

  公开号：US8754209B2

  公开（公告）日：2014-06-17
• [EN] NOVEL INDAZOLE DERIVATIVES OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF AS PROTEIN KINASE INHIBITORS FOR PROLIFERATIVE DISEASES TREATMENT, AND A PHARMACEUTICAL COMPOSITION CONTAINING THE SAME AS AN ACTIVE INGREDIENT<br/>[FR] NOUVEAUX DÉRIVÉS D'INDAZOLE OU SELS PHARMACEUTIQUEMENT ACCEPTABLES DE CEUX-CI EN TANT QU'INHIBITEURS DE PROTÉINE KINASE POUR LE TRAITEMENT DE MALADIES PROLIFÉRATIVES, ET COMPOSITION PHARMACEUTIQUE CONTENANT CEUX-CI EN TANT QUE SUBSTANCE ACTIVE
  申请人：KOREA INST SCI & TECH

  公开号：WO2010064875A2

  公开（公告）日：2010-06-10

  Disclosed are novel indazole derivatives represented by the following Chemical Formula 1 or pharmaceutically acceptable salts, hydrates or solvates thereof, and pharmaceutical compositions for the prevention or treatment of proliferative diseases, containing the same as an active ingredient. Having potent inhibitory effect against protein kinase, such as b-raf, KDR, Fms, Tie2, SAPK2a and Ret, inducing diseases caused by abnormal cell proliferation, the novel indazole derivatives can be used for the prevention or treatment of diseases caused by abnormal cell proliferation.