4-[(2-amino-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-amino]-benzoic acid | 57343-66-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 4-[(2-amino-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-amino]-benzoic acid
• 英文别名: 4-(((2-Amino-4-oxo-3,4-dihydroquinazolin-6-yl)methyl)amino)benzoic acid；4-[(2-amino-4-oxo-3H-quinazolin-6-yl)methylamino]benzoic acid
• CAS: 57343-66-5
• 化学式: C₁₆H₁₄N₄O₃
• 分子量: 310.312
• InChiKey: OKJTWJFPULDSSA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  23
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.06
• 拓扑面积：
  117
• 氢给体数：
  4
• 氢受体数：
  4

文献信息

• USE OF BUFFERS FOR RADIONUCLIDE COMPLEXATION
  申请人：GUERBET

  公开号：EP2396040B1

  公开（公告）日：2017-04-05
• COMPLEX FOLATE-NOTA-Ga68
  申请人：PORT Marc

  公开号：US20120064003A1

  公开（公告）日：2012-03-15

  The present invention concerns a Ga68 complex of formula FOLATE-(LINKER)i-NOTA-Ga 68 in which: 1) FOLATE is a folate compound or a derivative thereof capable of targeting a folate receptor, 2) NOTA is a chelate capable of complexing Ga68 having a NOTA scaffold or derivatives thereof 3) LINKER is a chemical group linking FOLATE and NOTA 4) i is an integer chosen between 0 and 1 wherein NOTA is complexing Ga68
• US8986650B2
  申请人：——

  公开号：US8986650B2

  公开（公告）日：2015-03-24
• [EN] USE OF BUFFERS FOR RADIONUCLIDE COMPLEXATION<br/>[FR] UTILISATION DE TAMPONS POUR LA COMPLEXATION DE RADIONUCLÉIDES
  申请人：GUERBET SA

  公开号：WO2010092114A1

  公开（公告）日：2010-08-19

  The present invention relates to a method for complexation of a chelate with a radionuclide, advantageously gallium, the complexation being carried out advantageously at ambient temperature without heating, by adding the radionuclide to the chelate in a buffer solution, the buffer of this solution comprising between two and five functions for coordination with the radionuclide, each coordination function being independently chosen from a carboxylic acid function and a hydroxyl function, on the condition that the buffer comprises at least one carboxylic acid function and at most two carboxylic acid functions. It also relates to the injectable solution obtained.