12α-Hydroxycholansaeure | 15152-40-6

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: 12α-Hydroxycholansaeure
• 英文别名: 4-[(5S,8R,9S,10S,12S,13R,14S,17R)-12-hydroxy-10,13-dimethyl-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoic acid
• CAS: 15152-40-6；15173-22-5；15173-23-6；30627-80-6；77059-18-8；106862-78-6
• 化学式: C₂₄H₄₀O₃
• 分子量: 376.58
• InChiKey: OBUOWZOYJNAMCZ-SVPLJSFISA-N

物化性质

• 沸点：
  511.1±23.0 °C(Predicted)
• 密度：
  1.073±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  6.6
• 重原子数：
  27
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.96
• 拓扑面积：
  57.5
• 氢给体数：
  2
• 氢受体数：
  3

文献信息

• Process for the preparation of deoxycholic acid
  申请人：Glenmark Life Sciences Limited

  公开号：US10858387B2

  公开（公告）日：2020-12-08

  The present invention provides a process for preparation of deoxycholic acid or salt thereof; the process comprises the steps of reacting the compound of formula II to obtain a compound of formula III; the compound of formula III is converted to a compound of formula IV and the compound of formula IV is converted to deoxycholic acid. The present invention also provides a process for the purification of deoxycholic acid or salt thereof.

  本发明提供了一种制备脱氧胆酸或其盐的工艺；该工艺包括以下步骤：使式 II 化合物反应得到式 III 化合物；式 III 化合物转化为式 IV 化合物，式 IV 化合物转化为脱氧胆酸。本发明还提供了一种纯化脱氧胆酸或其盐的工艺。
• METHODS OF USING FGF19 MODULATORS
  申请人：F. Hoffmann-La Roche AG

  公开号：EP2804630B1

  公开（公告）日：2017-10-18
• PROCESS FOR THE PREPARATION OF DEOXYCHOLIC ACID
  申请人：Glenmark Life Sciences Limited

  公开号：US20200140478A1

  公开（公告）日：2020-05-07

  The present invention provides a process for preparation of deoxycholic acid or salt thereof; the process comprises the steps of reacting the compound of formula II to obtain a compound of formula III; the compound of formula III is converted to a compound of formula IV and the compound of formula IV is converted to deoxycholic acid. The present invention also provides a process for the purification of deoxycholic acid or salt thereof.