4,9-dihydroxy-1,3-di(4-chlorophenyl)-2,3-dihydro-2-azaphenalene | 1229039-10-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 4,9-dihydroxy-1,3-di(4-chlorophenyl)-2,3-dihydro-2-azaphenalene
• 英文别名: 1,3-bis(4-chlorophenyl)-2,3-dihydro-1H-benzo[de]isoquinoline-4,9-diol
• CAS: 1229039-10-4
• 化学式: C₂₄H₁₇Cl₂NO₂
• 分子量: 422.31
• InChiKey: QVSWZZRTKCICCT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6
• 重原子数：
  29
• 可旋转键数：
  2
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  52.5
• 氢给体数：
  3
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2,7-二羟基萘 、 4-氯苯甲醛 在 diammonium hydrogenphosphate 作用下， 以 乙醇 、 水 为溶剂， 反应 8.0h， 以90%的产率得到4,9-dihydroxy-1,3-di(4-chlorophenyl)-2,3-dihydro-2-azaphenalene
  参考文献：
  名称：

  通过一锅多组分反应合成新型 1,3-二苯基-2-氮杂菲那烯衍生物的简单有效程序

  摘要：

  两分子芳香醛与 2,7-萘二醇和磷酸氢铵的新型单锅多组分反应被描述为一种有效且直接的制备混合物中新型 1,3-二苯基-2-氮杂苯衍生物的方法EtOH-H2O (3:1) 在回流条件下。

  DOI：

  10.1080/00397910903161835

文献信息

• [EN] ALPHA-HYDROGEN SUBSTITUTED NITROXYLS AND DERIVATIVES THEREOF AS CATALYSTS<br/>[FR] NITROXYLES À SUBSTITUTION ALPHA-HYDROGÈNE ET LEURS DÉRIVÉS EN TANT QUE CATALYSEURS
  申请人：TECHNION RES & DEV FOUNDATION

  公开号：WO2013118118A1

  公开（公告）日：2013-08-15

  The present invention relates to novel alpha-hydrogen substituted nitroxyl compounds and their corresponding oxidized (oxoammonium cations) and reduced (hydroxylamine) forms, and to the use of such compounds, inter alia, for (1) oxidation of primary and secondary alcohols to aldehydes and ketones, respectively; (2) resolution of racemic alcohols; (3) desymmetrization of meso-alcohol; (4) as radicals and spin trapping reagents; and (5) as polymerization agents. The present invention further relates to processes for preparing the novel nitroxyl/oxoammonium/ hydroxylamine compounds from the corresponding amines, and to certain novel amine derivatives and their uses. The compounds of the invention as well as the amine precursors are also useful as ligands for transition metals and as organocatalysts in e.g., aldol reactions.

  本发明涉及新型α-氢取代亚硝基化合物及其相应的氧化物（氧化氨阳离子）和还原物（羟胺）形式的使用，其中这些化合物可用于（1）将一级和二级醇氧化为醛和酮；（2）拆分外消旋醇；（3）去对称化中性醇；（4）作为自由基和自旋捕获试剂；以及（5）作为聚合剂。本发明还涉及从相应胺制备新型亚硝基/氧化氨/羟胺化合物的方法，以及某些新型胺衍生物及其用途。本发明的化合物以及胺前体也可用作过渡金属的配体，并可用作有机催化剂，例如在Aldol反应中。
• Alpha-Hydrogen Substituted Nitroxyls And Derivatives Thereof As Catalysts
  申请人：Technion Research and Development Foundation Ltd.

  公开号：US20140350258A1

  公开（公告）日：2014-11-27

  Novel alpha-hydrogen substituted nitroxyl compounds and their corresponding oxidized (oxoammonium cations) and reduced (hydroxylamine) forms, and the use of such compounds, inter alia, for oxidation of primary and secondary alcohols to aldehydes and ketones, respectively; resolution of racemic alcohols; desymmetrization of meso-alcohol; as radicals and spin trapping reagents; and as polymerization agents. Processes for preparing the novel nitroxyl/oxoammonium/hydroxylamine compounds from the corresponding amines, and certain novel amine derivatives and their uses. The compounds and amine precursors are useful as ligands for transition metals and as organocatalysts in e.g., aldol reactions.
• US9475774B2
  申请人：——

  公开号：US9475774B2

  公开（公告）日：2016-10-25
• Simple and Efficient Procedure for the Synthesis of Novel 1,3-Diphenyl-2-azaphenalene Derivatives via One-Pot Multicomponent Reactions
  作者：Naser Foroughifar、Akbar Mobinikhaledi、Hassan Moghanian

  DOI：10.1080/00397910903161835

  日期：2010.5.19

  A new, one-pot multicomponent reaction of two molecules of aromatic aldehydes with 2,7-naphthalenediol and ammonium hydrogen phosphate is described as an efficient and direct procedure for the preparation of novel 1,3-diphenyl-2-azaphenalene derivatives in a mixture of EtOH-H2O (3:1) under reflux conditions.

  两分子芳香醛与 2,7-萘二醇和磷酸氢铵的新型单锅多组分反应被描述为一种有效且直接的制备混合物中新型 1,3-二苯基-2-氮杂苯衍生物的方法EtOH-H2O (3:1) 在回流条件下。