3,6-Anhydro-D-glucose | 15206-46-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氧环庚烷
• 英文名称: 3,6-Anhydro-D-glucose
• 英文别名: 3,6-Anhydro-D-glucopyranose；(1R,4R,5S,8R)-2,6-dioxabicyclo[3.2.1]octane-3,4,8-triol
• CAS: 15206-46-9
• 化学式: C₆H₁₀O₅
• 分子量: 162.142
• InChiKey: DCQFFOLNJVGHLW-RSVSWTKNSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.1
• 重原子数：
  11
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  79.2
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• Pharmaceutical compositions comprising peranhydrocyclodextrine
  申请人：Novartis AG

  公开号：EP2289557A1

  公开（公告）日：2011-03-02

  The present invention relates to a pharmaceutical composition comprising a peranhydrocyclodextrin, a drug and a carries, to the use of peranhydrocyclodextrin as a drug transport enhancer (e.g., permeation enhancer), and to the use of a peranhydrocyclodextrin in the preparation of a pharmaceutical composition as a synergistic adjunctive system.

  本发明涉及一种由全氢环糊精、药物和载体组成的药物组合物，涉及全氢环糊精作为药物转运增强剂（如渗透增强剂）的用途，以及涉及全氢环糊精在制备药物组合物中作为协同辅助系统的用途。
• B-cyclodextrin derivatives and their use against anthrax lethal toxin
  申请人：Karginov Vladimir

  公开号：US20060247208A1

  公开（公告）日：2006-11-02

  The invention provides low molecular weight compounds that block the pore formed by protective antigen and inhibit anthrax toxin action. Structures of the compounds are derivatives of β-cyclodextrin. Per-substituted alkylamino derivates displayed inhibitory activity, and they were protective against anthrax lethal toxin action at low micromolar concentrations. Also, the addition of one of the alkylamino derivatives to the bilayer lipid membrane with multiple PA channels caused a significant decrease in membrane conductance. Thus, the invention also provides methods for protection against anthrax toxicity.

  本发明提供的低分子量化合物可阻塞保护性抗原形成的孔隙，抑制炭疽毒素的作用。这些化合物的结构是β-环糊精的衍生物。过取代的烷基氨基衍生物具有抑制活性，在低微摩尔浓度下对炭疽致死毒素的作用具有保护作用。此外，在具有多个 PA 通道的双层脂膜中加入一种烷基氨基衍生物会显著降低膜传导性。因此，本发明还提供了防止炭疽毒性的方法。
• PHARMACEUTICAL COMPOSITIONS COMPRISING PERANHYDROCYCLODEXTRIN
  申请人：Novartis AG

  公开号：EP1646405A1

  公开（公告）日：2006-04-19
• BETA-CYCLODEXTRIN DERIVATIVES AND THEIR USE AGAINST ANTHRAX LETHAL TOXIN
  申请人：Pinnacle Pharmaceuticals

  公开号：EP1735326A2

  公开（公告）日：2006-12-27
• Pharmaceutical compositions comprising peranhydrocyclodextrin
  申请人：Szente Lajos

  公开号：US20070042994A1

  公开（公告）日：2007-02-22

  The present invention relates to a pharmaceutical composition comprising a peranhydrocyclodextrin a drug and a carrier, to the use of a peranhydrocyclodextrin as a drug transport enhancer (e.g. permeation enhancer), and to the use of a peranhydrocyclodextrin in the preparation of a pharmaceutical composition as a synergistic adjunctive system.