N,N'-bis[(S)-(1-(1-naphthyl)ethyl)]ethane-1,2-diamine | 701209-43-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: N,N'-bis[(S)-(1-(1-naphthyl)ethyl)]ethane-1,2-diamine
• 英文别名: N,N'-bis[(1S)-1-naphthalen-1-ylethyl]ethane-1,2-diamine
• CAS: 701209-43-0
• 化学式: C₂₆H₂₈N₂
• 分子量: 368.522
• InChiKey: CHONRKGFXILFQP-PMACEKPBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.7
• 重原子数：
  28
• 可旋转键数：
  7
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  24.1
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  N,N'-bis[(S)-(1-(1-naphthyl)ethyl)]ethane-1,2-diamine 在 三乙胺 、 三氯化磷 作用下， 以 二氯甲烷 为溶剂， 反应 10.0h， 生成
  参考文献：
  名称：

  Enantioselective Ni–Al Bimetallic Catalyzed exo-Selective C–H Cyclization of Imidazoles with Alkenes

  摘要：

  A Ni-Al bimetallic catalyzed enantioselective C-H exo-selective cyclization of imidazoles with alkenes has been developed. A series of bi- or polycyclic imidazoles with beta-stereocenter were obtained in up to 98% yield and >99% ee. The bifunctional SPO ligand-promoted bimetallic catalysis proved to be critical to this challenging stereocontrol.

  DOI：

  10.1021/jacs.8b02547
• 作为产物：
  描述：

  N,N'-bis[(S)-1-naphthyl-ethyl]ethanediimine 在 sodium tetrahydroborate 作用下， 以 甲醇 为溶剂， 生成 N,N'-bis[(S)-(1-(1-naphthyl)ethyl)]ethane-1,2-diamine
  参考文献：
  名称：

  环己烯氧化物与新的同手性双锂酰胺碱的对映选择性催化重排

  摘要：

  环己烯氧化物可以以良好的诱导水平（高达68％ee）进行重排，亚化学计量量的衍生自易于获得的二胺的手性碱。还研究了胺取代基的空间体积对重排对映选择性的影响。

  DOI：

  10.1016/j.tetasy.2004.02.030

文献信息

• Chiral bidentate aminophosphine ligands: synthesis, coordination chemistry and asymmetric catalysis
  作者：Eric J. Zijp、Jarl Ivar van der Vlugt、Duncan M. Tooke、Anthony L. Spek、Dieter Vogt

  DOI：10.1039/b414668a

  日期：——

  determine the electronic character of the phosphine moieties. By reaction of 1 with either PdCl2(cod) or PdCl(CH3)(cod) the cis-complexes 7 and 8 were obtained. The molecular structure for complex 7, cis-[PdCl2(1)], was determined by X-ray crystallography. Reaction of PtCl2(cod) with 1 or 2 yielded the corresponding monomeric cis-isomers 9 and 10. The rhodium derivative [RhCl(CO)(1)] (11) was obtained

  手性氨基膦Ph2PN（R）（CH2）nN（R）PPh2 1-4 [n = 2，R = CH（CH3）（Ph）1; n ＝ 3，R ＝ CH（CH 2 CH 3）（Ph）2，n ＝ 2，R ＝ CH（CH 3）（1-萘基）3。n = 2，R = CH（CH3）（C6H11）4]是通过ClPPh2与适当的容易获得的对映纯胺结构单元反应合成的。对于化合物1和2，制备相应的硒化物5和6以确定膦部分的电子特性。通过1与PdCl2（cod）或PdCl（CH3）（cod）的反应获得顺式配合物7和8。配合物7，顺式[PdCl2（1）]的分子结构通过X射线晶体学测定。PtCl2（cod）与1或2的反应产生相应的单体顺式异构体9和10。以顺式和反式异构体的混合物形式得到铑衍生物[RhCl（CO）（1）]（11）。
• Enantioselective Ni–Al Bimetallic Catalyzed <i>exo</i>-Selective C–H Cyclization of Imidazoles with Alkenes
  作者：Yin-Xia Wang、Shao-Long Qi、Yu-Xin Luan、Xing-Wang Han、Shan Wang、Hao Chen、Mengchun Ye

  DOI：10.1021/jacs.8b02547

  日期：2018.4.25

  A Ni-Al bimetallic catalyzed enantioselective C-H exo-selective cyclization of imidazoles with alkenes has been developed. A series of bi- or polycyclic imidazoles with beta-stereocenter were obtained in up to 98% yield and >99% ee. The bifunctional SPO ligand-promoted bimetallic catalysis proved to be critical to this challenging stereocontrol.
• Enantioselective catalytic rearrangement of cyclohexene oxide with new homochiral bis-lithium amide bases
  作者：Olivier Equey、Alexandre Alexakis

  DOI：10.1016/j.tetasy.2004.02.030

  日期：2004.4

  Cyclohexene oxide can be rearranged with good levels of induction (up to 68% ee) with substoichiometric amounts of chiral bases derived from readily available diamines. The influence of the steric bulk of the amine substituents on the rearrangement enantioselectivity has also been studied.

  环己烯氧化物可以以良好的诱导水平（高达68％ee）进行重排，亚化学计量量的衍生自易于获得的二胺的手性碱。还研究了胺取代基的空间体积对重排对映选择性的影响。