2-{2-[2-(4-fluoro-phenyl)-1H-imidazol-4-yl]-ethyl}-5,8-dimethyl-[1,2,4]triazolo[1,5-a]pyrazine | 1312325-63-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡唑并嘧啶类
• 英文名称: 2-{2-[2-(4-fluoro-phenyl)-1H-imidazol-4-yl]-ethyl}-5,8-dimethyl-[1,2,4]triazolo[1,5-a]pyrazine
• 英文别名: US8927738, 2-{2-[2-(4-Fluoro-phenyl)-1H-imidazol-4-yl]-ethyl}-5,8-dimethyl-[1,2,4]triazolo[1,5-a]pyrazine；2-[2-[2-(4-fluorophenyl)-1H-imidazol-5-yl]ethyl]-5,8-dimethyl-[1,2,4]triazolo[1,5-a]pyrazine
• CAS: 1312325-63-5
• 化学式: C₁₈H₁₇FN₆
• 分子量: 336.372
• InChiKey: BQSJMWPUWDBBHP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  25
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  71.8
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• [EN] 2-ARYLIMIDAZOLE DERIVATIVES AS PDE10A ENZYME INHIBITORS<br/>[FR] DÉRIVÉS DE 2-ARYLIMIDAZOLE EN TANT QU'INHIBITEURS DE L'ENZYME PDE10A
  申请人：LUNDBECK & CO AS H

  公开号：WO2011072696A1

  公开（公告）日：2011-06-23

  This invention is directed to compounds, which are PDE10A enzyme inhibitors. The invention provides a pharmaceutical composition comprising a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. The present invention also provides processes for the preparation of the compounds of formula (I). The present invention further provides a method of treating a subject suffering from a neurodegenerative disorder comprising administering to the subject a therapeutically effective amount of a compound of formula (I). The present invention also provides a method of treating a subject suffering from a drug addiction comprising administering to the subject a therapeutically effective amount of a compound of formula (I). The present invention further provides a method of treating a subject suffering from a psychiatric disorder comprising administering to the subject a therapeutically effective amount of a compound of formula (I).

  这项发明涉及一类PDE10A酶抑制剂化合物。该发明提供了一种包含本发明化合物的治疗有效量和药学可接受载体的药物组合物。本发明还提供了制备式(I)化合物的方法。本发明进一步提供了一种治疗神经退行性疾病的方法，包括向患有神经退行性疾病的对象施用式(I)化合物的治疗有效量。本发明还提供了一种治疗药物成瘾的方法，包括向患有药物成瘾的对象施用式(I)化合物的治疗有效量。本发明还提供了一种治疗精神障碍的方法，包括向患有精神障碍的对象施用式(I)化合物的治疗有效量。
• 2-ARYLIMIDAZOLE DERIVATIVES AS PDE10A ENZYME INHIBITORS
  申请人：Püschl Ask

  公开号：US20120302548A1

  公开（公告）日：2012-11-29

  This invention is directed to compounds, which are PDE10A enzyme inhibitors. The invention provides a pharmaceutical composition comprising a therapeutically effective amount of a compound of the invention and a pharmaceutically acceptable carrier. The present invention also provides processes for the preparation of the compounds of formula I. The present invention further provides a method of treating a subject suffering from a neurodegenerative disorder comprising administering to the subject a therapeutically effective amount of a compound of formula I. The present invention also provides a method of treating a subject suffering from a drug addiction comprising administering to the subject a therapeutically effective amount of a compound of formula I. The present invention further provides a method of treating a subject suffering from a psychiatric disorder comprising administering to the subject a therapeutically effective amount of a compound of formula I.

  本发明涉及一种PDE10A酶抑制剂化合物。本发明提供一种药物组合物，该药物组合物包括本发明的化合物的治疗有效量和药学上可接受的载体。本发明还提供了制备式I化合物的方法。本发明还提供了一种治疗神经退行性疾病的方法，包括向患者施用式I化合物的治疗有效量。本发明还提供了一种治疗药物成瘾的方法，包括向患者施用式I化合物的治疗有效量。本发明还提供了一种治疗精神障碍的方法，包括向患者施用式I化合物的治疗有效量。
• GAS SEPARATION MEMBRANE AND METHOD FOR PRODUCING THE SAME, AND METHOD FOR SEPARATING GAS MIXTURE, GAS SEPARATION MEMBRANE MODULE AND GAS SEPARATION APPARATUS USING THE SAME
  申请人：Sano Satoshi

  公开号：US20130014642A1

  公开（公告）日：2013-01-17

  The gas separation membrane of the present invention provides a gas separation membrane that exhibits superior gas permeability and separation selectivity and plasticity to the extent that it can endure bending testing and has little pinholes and a method for producing the gas separation membrane. Through the gas separation membrane of the present invention, it is possible to provide a superior gas separation method, a gas separation membrane module, and a gas separation and purification apparatus including the gas separation membrane module. Through the gas separation membrane of the present invention, it is possible to provide a superior gas separation method, a gas separation membrane module, and a gas separation apparatus including the gas separation membrane module. The gas separation membrane of the present invention exhibits superior gas separation selectivity, in particular, carbon dioxide permeability, and exerts superior performance as a separation membrane of carbon dioxide/methane, carbon dioxide/hydrogen. Through the gas separation membrane and the composite membrane of the present invention, it is possible to provide a superior gas separation method, a gas separation membrane module, and a gas separation and purification apparatus including the gas separation membrane module. A gas separation membrane having a separation-active membrane containing a compound represented by the following Formula (I) having a boiling point or a decomposition temperature of 200° C. or higher and a cross-linked polymer having a dissociable group and a repeating unit derived from alkylene glycol, wherein the gas separation membrane separates at least one acid gas from a gas mixture containing the at least one acid gas and at least one non-acid gas.
• GAS SEPARATION COMPOSITE MEMBRANE AND METHOD OF PRODUCING THE SAME, AND GAS SEPARATING MODULE, GAS SEPARATION APPARATUS AND GAS SEPARATION METHOD USING THE SAME
  申请人：FUJIFILM Corporation

  公开号：US20140130667A1

  公开（公告）日：2014-05-15

  A gas separation composite membrane, containing a gas-permeable supporting layer and a gas separating layer containing a crosslinked polyimide resin over the gas-permeable supporting layer, in which the crosslinked polyimide resin is formed by a polyimide compound being crosslinked by a radically crosslinkable functional group thereof, and a ratio [η] of a crosslinked site to an imide group of the polyimide compound (the number of crosslinked sites/the number of imide groups) in the crosslinked polyimide resin is 0.0001 or more and 0.45 or less; a method of producing the same; and a gas separating module, a gas separation apparatus and a gas separation method using the same.
• GAS SEPARATION COMPOSITE MEMBRANE AND GAS SEPARATING MODULE, GAS SEPARATION APPARATUS AND GAS SEPARATION METHOD USING THE SAME
  申请人：FUJIFILM Corporation

  公开号：US20140130668A1

  公开（公告）日：2014-05-15

  A gas separation composite membrane, containing a gas-permeable supporting layer and a gas separating layer containing a crosslinked polyimide resin over the gas-permeable supporting layer, in which the crosslinked polyimide resin has structure in which a polyimide compound is crosslinked through a specific crosslinking chain, the specific crosslinking chain has at least one kind of linking group selected from the group consisting of —NR a C(═O)—, —NR b C(═O)O—, —CH 2 OCH 2 —, —CH 2 SCH 2 —, —OC(═O)O—, —C(═O)O − N + (R c ) 3 —, —SO 3 − N + (R d ) 3 — and —PO 3 − N + (R e ) 3 —, and R a , R b , R c , R d and R e each independently represent a hydrogen atom or a substituent.