(R)-N-((1S,2R)-2-fluorocyclohexyl)-2-methylpropane-2-sulfinamide | 1335302-61-8

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 卤代烷
• 英文名称: (R)-N-((1S,2R)-2-fluorocyclohexyl)-2-methylpropane-2-sulfinamide
• CAS: 1335302-61-8
• 化学式: C₁₀H₂₀FNOS
• 分子量: 221.339
• InChiKey: RBARAJNJISIHRS-TVLCNXBWSA-N

物化性质

• 沸点：
  316.5±52.0 °C(Predicted)
• 密度：
  1.10±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted)

反应信息

• 作为反应物：
  描述：

  (R)-N-((1S,2R)-2-fluorocyclohexyl)-2-methylpropane-2-sulfinamide 在 盐酸 作用下， 以 1,4-二氧六环 为溶剂， 以98%的产率得到(1S,2R)-2-fluorocyclohexanamine hydrochloride
  参考文献：
  名称：

  Highly Diastereoselective and General Synthesis of Primary β-Fluoroamines

  摘要：

  A short, high yielding protocol has been developed for the highly diastereoselective (dr >20:1) and general synthesis of primary beta-fluoroamines by the enantioselective alpha-fluorination of aldehydes, conversion into the N-sulfinyl aldimlne, nucleophilic addition of various organometallic species, and 1 degrees amine liberation.

  DOI：

  10.1021/ol202415j
• 作为产物：
  描述：

  (R)-N-((5R)-5-fluoroocta-1,7-dien-4-yl)-2-methylpropane-2-sulfinamide 在 RuCl2(1,3-dimesityl-imidazolidin-2-yl)(PCy3)(=CHPh) 、 palladium 10% on activated carbon 、 氢气 作用下， 以 乙醇 、 二氯甲烷 为溶剂， 生成 (R)-N-((1S,2R)-2-fluorocyclohexyl)-2-methylpropane-2-sulfinamide
  参考文献：
  名称：

  Highly Diastereoselective and General Synthesis of Primary β-Fluoroamines

  摘要：

  A short, high yielding protocol has been developed for the highly diastereoselective (dr >20:1) and general synthesis of primary beta-fluoroamines by the enantioselective alpha-fluorination of aldehydes, conversion into the N-sulfinyl aldimlne, nucleophilic addition of various organometallic species, and 1 degrees amine liberation.

  DOI：

  10.1021/ol202415j