6-(β-napthyl)-2-(4-sulfamoylphenyl)-4,5-dihydropyridazin-3(2H)-one | 1355614-08-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: 6-(β-napthyl)-2-(4-sulfamoylphenyl)-4,5-dihydropyridazin-3(2H)-one
• 英文别名: 4-(3-Naphthalen-2-yl-6-oxo-4,5-dihydropyridazin-1-yl)benzenesulfonamide
• CAS: 1355614-08-2
• 化学式: C₂₀H₁₇N₃O₃S
• 分子量: 379.439
• InChiKey: IQROKQIONYVTBU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  27
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  101
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  萘 在 aluminum (III) chloride 作用下， 以 乙醇 为溶剂， 反应 54.5h， 生成 6-(β-napthyl)-2-(4-sulfamoylphenyl)-4,5-dihydropyridazin-3(2H)-one
  参考文献：
  名称：

  Synthesis and biological evaluation of some novel sulfamoylphenyl-pyridazinone as anti-inflammatory agents (Part-II)

  摘要：

  Seven novel 6-aryl-2-(p-sulfamoylphenyl)-4,5-dihydropyridazin-3(2H)-ones (2a-g) were synthesized by the condensation of appropriate aroylpropionic acid and 4-hydrazinobenzenesulfonamide hydrochloride in ethanol. Structure of all compounds have been elucidated by elemental analysis, IR, H-1 NMR, C-13 NMR, DEPT and MS spectrscopy. These compounds were tested for their anti-inflammatory activity in carrageenan-induced rat paw edema model. Compound 2b exhibited anti-inflammatory activity comparable to that of celecoxib (at 5 h). Two other compounds 2d and 2g showed promising anti-inflammatory activity (edema reduction more than 80% at 5 h). These compounds (2b, 2d and 2g) did not produce any ulceration in gastric region.

  DOI：

  10.3109/14756366.2011.577036

文献信息

• Synthesis and biological evaluation of some novel sulfamoylphenyl-pyridazinone as anti-inflammatory agents (Part-II)
  作者：Rafia Bashir、Shafiya Yaseen、Syed Ovais、Shamim Ahmad、Hinna Hamid、M.S. Alam、Mohammad Samim、Kalim Javed

  DOI：10.3109/14756366.2011.577036

  日期：2012.2.1

  Seven novel 6-aryl-2-(p-sulfamoylphenyl)-4,5-dihydropyridazin-3(2H)-ones (2a-g) were synthesized by the condensation of appropriate aroylpropionic acid and 4-hydrazinobenzenesulfonamide hydrochloride in ethanol. Structure of all compounds have been elucidated by elemental analysis, IR, H-1 NMR, C-13 NMR, DEPT and MS spectrscopy. These compounds were tested for their anti-inflammatory activity in carrageenan-induced rat paw edema model. Compound 2b exhibited anti-inflammatory activity comparable to that of celecoxib (at 5 h). Two other compounds 2d and 2g showed promising anti-inflammatory activity (edema reduction more than 80% at 5 h). These compounds (2b, 2d and 2g) did not produce any ulceration in gastric region.