2-Di-n-propylamino-8-(isoxazol-5-yl)-1,2,3,4-tetrahydronaphthalene | 143918-77-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 四氢化萘
• 英文名称: 2-Di-n-propylamino-8-(isoxazol-5-yl)-1,2,3,4-tetrahydronaphthalene
• 英文别名: 8-(isoxazol-5-yl)-2-di-n-propylamino-1,2,3,4-tetrahydronaphthalene；2-Naphthalenamine, 1,2,3,4-tetrahydro-8-(5-isoxazolyl)-N,N-dipropyl-；8-(1,2-oxazol-5-yl)-N,N-dipropyl-1,2,3,4-tetrahydronaphthalen-2-amine
• CAS: 143918-77-8
• 化学式: C₁₉H₂₆N₂O
• 分子量: 298.428
• InChiKey: OAPKLRKDZATNCA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  22
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  29.3
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• Ring-substituted 2-amino-1,2,3,4-tetra-hydronaphthalenes
  申请人：ELI LILLY AND COMPANY

  公开号：EP0498590A1

  公开（公告）日：1992-08-12

  The present invention provides novel ring-substituted 2-amino-1,2,3,4-tetrahydronaphthalenes and 3-aminochromanes which exhibit binding activity at the serotonin 1A receptor.

  本发明提供了新型环取代的 2-氨基-1,2,3,4-四氢萘和 3-氨基色烷，它们在血清素 1A 受体上表现出结合活性。
• 5-Ht1A agonists for improving primary memory and/or learning
  申请人：ELI LILLY AND COMPANY

  公开号：EP0565274A1

  公开（公告）日：1993-10-13

  This invention is based on the observation that the administration to a mamal of a selective 5-HT1A agonist, e.g. 8-OH-DPAT or (±)-4-(di-n-propyl)amino-6-methoxy-1,3,4,5-tetrahydrobenz[c,d]indole, or a pharmaceutically acceptable salt thereof, induces hippocampal theta rhythm associated with primary (i.e. short-term) memory, and learning functions.

  本发明基于以下观察结果：给马骡服用选择性 5-HT1A 激动剂，例如 8-OH-DPAT 或 (±)-4-(di-n-propyl)amino-6-methoxy-1,3,4,5-tetrahydrobenz[c,d]indole 或其药学上可接受的盐，可诱导与初级（即短期）记忆和学习功能相关的海马θ节律。
• Isoxazole derivatives for the treatment of irritable bowel syndrome
  申请人：ELI LILLY AND COMPANY

  公开号：EP0579507A1

  公开（公告）日：1994-01-19

  Provided is a method of treating Irritable Bowel Syndrome (IBS) using a series of isoxazole derivatives that have both 5-HT1A agonist and M1 muscarinic activities, and formulations suitable therefor.

  本发明提供了一种利用一系列同时具有 5-HT1A 激动剂和 M1 肌松素活性的异噁唑衍生物治疗肠易激综合征（IBS）的方法，以及适用于该方法的制剂。
• Ring-substituted 2-amino-1,2,3,4-tetra-hydronaphthalenes and 3-aminochromanes
  申请人：ELI LILLY AND COMPANY

  公开号：EP0712837A2

  公开（公告）日：1996-05-22

  The present invention provides novel ring-substituted 2-amino-1,2,3,4-tetrahydronaphthalenes and 3-aminochromanes which exhibit binding activity at the serotonin 1A receptor.

  本发明提供了新型环取代的 2-氨基-1,2,3,4-四氢萘和 3-氨基色烷，它们在血清素 1A 受体上表现出结合活性。
• ANTIOXIDANT STABILIZER SYSTEM FOR PHARMACEUTICAL FORMULATIONS
  申请人：ROBERTS LABORATORIES INC.

  公开号：EP1067927B1

  公开（公告）日：2006-03-01