N^im-benzylhistamine | 82830-42-0

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N^im-benzylhistamine
• 英文别名: 2-(3-benzyl-3H-imidazol-4-yl)-ethylamine；2-(3-Benzyl-3H-imidazol-4-yl)-aethylamin；2-(3-Benzylimidazol-4-yl)ethanamine
• CAS: 82830-42-0
• 化学式: C₁₂H₁₅N₃
• 分子量: 201.271
• InChiKey: XSDYRVQWQJIFRI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  15
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  43.8
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  N^im-benzylhistamine 在 盐酸 、 1-羟基苯并三唑 、 二异丙胺 、 N,N'-二环己基碳二亚胺 作用下， 以 水 、 乙腈 为溶剂， 反应 53.0h， 生成 5-(diphenylacetyl)-4,5,6,7-tetrahydro-1-(phenylmethyl)-1H-imidazo<4,5-c>pyridine
  参考文献：
  名称：

  Synthesis and structure-activity relationships of a novel series of non-peptide angiotensin II receptor binding inhibitors specific for the AT2 subtype

  摘要：

  Structure-activity relationships are reported for a novel class of 4,5,6,7-tetrahydro-1H-imidazo[4,5-c]pyridine-6-carboxylic acid derivatives that displace I-125-labeled angiotensin II from a specific subset of angiotensin II (Ang II) binding sites in rat adrenal preparations. This binding site is not the Ang II receptor mediating vascular contraction or aldosterone release, but, rather, is one whose function has not yet been fully elucidated. It has been identified in a number of tissues and has a similar affinity for Ang II and its peptide analogues as does the vascular receptor. The non-peptide compounds reported here are uniquely specific in displacing Ang II at this binding site and are inactive in antagonizing Ang II at the vascular receptor or in pharmacological assays measuring vascular effects. PD 123,319 (79), one of the most potent compounds, has an IC50 of 34 nM. Certain of these compounds may have utility in the definition and study of Ang II receptor subtypes.

  DOI：

  10.1021/jm00115a014

文献信息

• Substituted N-(imidazolyl)alkyl alanine derivatives
  申请人：SMITHKLINE BEECHAM CORPORATION

  公开号：EP0427463A1

  公开（公告）日：1991-05-15

  Angiotensin II receptor antagonists having the formula: which are useful in regulating hypertension and in the treatment of congestive heart failure, renal failure, and glaucoma, pharmaceutical compositions including these antagonists, and methods of using these compounds to produce angiotensin II receptor antagonism in mammals.

  式的血管紧张素 II 受体拮抗剂： 用于调节高血压和治疗充血性心力衰竭、肾功能衰竭和青光眼的血管紧张素 II 受体拮抗剂，包括这些拮抗剂的药物组合物，以及使用这些化合物在哺乳动物体内产生血管紧张素 II 受体拮抗作用的方法。
• Substituted 5-(alkyl)carboxamide imidazoles
  申请人：SMITHKLINE BEECHAM CORPORATION

  公开号：EP0437103A2

  公开（公告）日：1991-07-17

  Angiotensin II receptor antagonists having the formula : which are useful in regulating hypertension and in the treatment of congestive heart failure, renal failure, and glaucoma pharmaceutical compositions including these antagonists, and methods of using these compounds to produce angiotensin II receptor antagonism in mammals.

  血管紧张素 II 受体拮抗剂，其分子式为： 可用于调节高血压和治疗充血性心力衰竭、肾功能衰竭和青光眼的包括这些拮抗剂的药物组合物，以及使用这些化合物在哺乳动物体内产生血管紧张素 II 受体拮抗作用的方法。
• US5248689A
  申请人：——

  公开号：US5248689A

  公开（公告）日：1993-09-28
• US5234917A
  申请人：——

  公开号：US5234917A

  公开（公告）日：1993-08-10
• US5444081A
  申请人：——

  公开号：US5444081A

  公开（公告）日：1995-08-22