DQ-2777 free base | 88372-35-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: DQ-2777 free base
• 英文别名: 2-naphthalen-1-yl-1-piperazin-1-ylethanone
• CAS: 88372-35-4
• 化学式: C₁₆H₁₈N₂O
• 分子量: 254.33
• InChiKey: FZTHQFULUIGZST-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  19
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  32.3
• 氢给体数：
  1
• 氢受体数：
  2

文献信息

• 5-HT receptor ligands and uses thereof
  申请人：——

  公开号：US20030105106A1

  公开（公告）日：2003-06-05

  Compounds of Formula (IA) that act as 5-HT receptor ligands and their uses in the treatment of diseases linked to the activation of 5-HT 2 receptors in animals are described herein. 1

  本文描述了作为5-HT受体配体的化合物（IA）及其在治疗与动物5-HT2受体激活相关的疾病中的用途。
• [EN] DIHYDROBENZOFURAN COMPOUNDS AND USES THEREOF<br/>[FR] COMPOSES DIHYDROBENZOFURANE ET LEURS UTILISATIONS
  申请人：PFIZER PROD INC

  公开号：WO2006000902A1

  公开（公告）日：2006-01-05

  Dihydrobenzofuran compounds of Formula (I), including salts, prodrugs, hydrates and solvates thereof, that act as 5-HT2 receptor ligands and their uses in the treatment of diseases linked to the activation of 5-HT2 receptors in animals are described herein. Formula (I).

  本文描述了公式(I)的二氢苯并呋喃化合物，包括其盐、前药、水合物和溶剂化合物，这些化合物作为5-HT2受体配体，并且它们在治疗与动物体内5-HT2受体激活相关的疾病中的用途。公式(I)。
• [EN] SEROTONIN LIGANDS AS PRO-ERECTILE COMPOUNDS<br/>[FR] LIGANDS DE SEROTONINE EN TANT QUE COMPOSES FAVORISANT L'ERECTION
  申请人：NORTRAN PHARMACEUTICALS INC

  公开号：WO2000028993A1

  公开（公告）日：2000-05-25

  Compounds, and compositions including the compounds, are effective to treat or prevent sexual dysfunction, (by, for example, providing a pro-erectile function), when those compounds display selective serotonin (5HT) receptor activity. In one aspect, the compound is a 5HT2c agonist and a 5HT2a antagonist. In another aspect, the compound is a 5HT2c agonist, a 5HT2a antagonist, and a 5HT1a agonist (weak).

  化合物和包含这些化合物的组合物，在表现出选择性血清素（5HT）受体活性时，对于治疗或预防性功能障碍（例如，提供勃起功能）是有效的。在一个方面，该化合物是5HT2c激动剂和5HT2a拮抗剂。在另一个方面，该化合物是5HT2c激动剂，5HT2a拮抗剂和5HT1a激动剂（弱）。
• [EN] 5-HT RECEPTOR LIGANDS AND USES THEREOF<br/>[FR] LIGANDS DES RECEPTEURS 5-HT ET LEURS UTILISATIONS
  申请人：PFIZER PROD INC

  公开号：WO2003000666A1

  公开（公告）日：2003-01-03

  Compounds of Formula (IA) that act as 5-HT receptor ligands and their uses in the treatment of diseases linked to the activation of 5-HT2 receptors in animals are described herein.

  本文描述了化学式（IA）的化合物，其作为5-HT受体配体，并用于治疗与动物中5-HT2受体激活相关的疾病。
• Cyclopentapyridine and tetrahydroquinoline derivatives
  申请人：Lefker A. Bruce

  公开号：US20060247254A1

  公开（公告）日：2006-11-02

  6,7-Dihydro-5H-cyclopenta[b]pyridine and 5,6,7,8-tetrahydroquinoline compounds of Formula (I), including salts, hydrates and solvates thereof, that act as 5-HT 2 receptor ligands and their uses in the treatment of diseases linked to the activation of 5-HT 2c receptors are described herein.

  本文介绍了公式(I)中的6,7-二氢-5H-环戊[b]吡啶和5,6,7,8-四氢喹啉化合物，包括其盐、水合物和溶剂化物，它们作为5-HT2受体配体，并且它们在治疗与5-HT2受体激活有关的疾病方面的用途。