(20S)-20-[(4-benzoylpiperidin-1-yl)methyl]-5α-pregna-5-en-3β-ol | 677309-56-7

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: (20S)-20-[(4-benzoylpiperidin-1-yl)methyl]-5α-pregna-5-en-3β-ol
• 英文别名: [1-[(2S)-2-[(3S,8S,9S,10R,13S,14S,17R)-3-hydroxy-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-17-yl]propyl]piperidin-4-yl]-phenylmethanone
• CAS: 677309-56-7
• 化学式: C₃₄H₄₉NO₂
• 分子量: 503.769
• InChiKey: OYCXQAKUBCMCEW-AESKLMAPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.5
• 重原子数：
  37
• 可旋转键数：
  5
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.74
• 拓扑面积：
  40.5
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• Steroid compounds, use of these compounds for the preparation of meiosis-regulating medicaments and method for the preparation of these compounds
  申请人：Schering AG

  公开号：US20020188143A1

  公开（公告）日：2002-12-12

  The present invention relates to steroid compounds of general formula X, which may advantageously be employed to stimulate meiosis in human oocytes, the steroid being specifically characterized by amino nitrogen bonded to C 17 of the steroid skeleton via a spacer A. 1

  本发明涉及通式X的类固醇化合物，这些化合物可优势地用于刺激人卵母细胞的减数分裂，该类固醇化合物的特征在于氨基氮通过间距A.1与类固醇骨架的C17键合。
• US6916921B2
  申请人：——

  公开号：US6916921B2

  公开（公告）日：2005-07-12
• [EN] USE OF MAS-COMPOUNDS FOR TREATING DISEASES ASSOCIATED WITH LIPID METABOLISM<br/>[FR] UTILISATION DE COMPOSES MAS POUR LE TRAITEMENT DES MALADIES ASSOCIEES AU METABOLISME DES LIPIDES
  申请人：NOVO NORDISK AS

  公开号：WO2004028544A1

  公开（公告）日：2004-04-08

  Certain sterols can be used for increasing the HDL cholesterol to non-HDL cholesterol ratio, for treatment and/or prevention of artherosclerosis, for treatment and/or prevention of hyper-lipidemia, for treatment of diabetic dyslipididemia, for treatment of hyper-cholesterolemia, for treatment of diseases of illness related to metabolic dysfunction, for treatment of obesity or obesitas related diseases, and for the treatment of neurological diseases.