N-([4-(3-chloro-4-fluorophenyl)amino]-7-{3-[4-(2-methoxyethyl)-1-piperazinyl]-3-methyl-1-butynyl}-6-quinazolinyl)acrylamide | 451493-14-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: N-([4-(3-chloro-4-fluorophenyl)amino]-7-{3-[4-(2-methoxyethyl)-1-piperazinyl]-3-methyl-1-butynyl}-6-quinazolinyl)acrylamide
• 英文别名: N-[4-(3-chloro-4-fluoroanilino)-7-[3-[4-(2-methoxyethyl)piperazin-1-yl]-3-methylbut-1-ynyl]quinazolin-6-yl]prop-2-enamide
• CAS: 451493-14-4
• 化学式: C₂₉H₃₂ClFN₆O₂
• 分子量: 551.063
• InChiKey: RYUNDKRGUZNXRW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  39
• 可旋转键数：
  10
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.34
• 拓扑面积：
  82.6
• 氢给体数：
  2
• 氢受体数：
  8

文献信息

• MOLECULAR CHAPERONE FUNCTION REGULATOR
  申请人：Mitsubishi Pharma Corporation

  公开号：EP1792898A1

  公开（公告）日：2007-06-06

  According to the present invention, a molecular chaperone function regulator containing a quinazoline derivative represented by the following formula (I) wherein each symbol is as defined in Claims, or a pharmaceutically acceptable salt thereof, a hydrate or solvate thereof, an optically active form or racemate thereof or a diastereomer mixture thereof as an active ingredient can be provided.

  根据本发明，一种分子伴侣功能调节剂含有下式（I）所代表的喹唑啉衍生物 其中各符号如权利要求中定义，或其药学上可接受的盐、其水合物或溶液、其光学活性形式或外消旋物或其非对映异构体混合物作为活性成分。
• Molecular Chaperone Function Regulator
  申请人：Suzuki Tsuyoshi

  公开号：US20080200433A1

  公开（公告）日：2008-08-21

  According to the present invention, a molecular chaperone function regulator containing a quinazoline derivative represented by the following formula (I) wherein each symbol is as defined in Claims, or a pharmaceutically acceptable salt thereof, a hydrate or solvate thereof, an optically active form or racemate thereof or a diastereomer mixture thereof as an active ingredient can be provided.