(E)-3-methyl-6-(naphthalen-1-yl)hex-3-en-1-ol | 1222923-58-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: (E)-3-methyl-6-(naphthalen-1-yl)hex-3-en-1-ol
• CAS: 1222923-58-1
• 化学式: C₁₇H₂₀O
• 分子量: 240.345
• InChiKey: PYCSDEAVPINNJC-MKMNVTDBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  18.0
• 可旋转键数：
  5.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  20.23
• 氢给体数：
  1.0
• 氢受体数：
  1.0

反应信息

• 作为反应物：
  描述：

  丁二酰亚胺 、 (E)-3-methyl-6-(naphthalen-1-yl)hex-3-en-1-ol 在 偶氮二甲酸二叔丁酯 、 三苯基膦 作用下， 以 四氢呋喃 为溶剂， 以93%的产率得到(E)-1-(3-methyl-6-(naphthalen-1-yl)hex-3-en-1-yl)pyrrolidine-2,5-dione
  参考文献：
  名称：

  Enantioselective Thiourea-Catalyzed Cationic Polycyclizations

  摘要：

  A new thiourea catalyst is reported for the enantioselective cationic polycyclization of hydroxylactams. Both the yield and enantioselectivity of this transformation were found to vary strongly with the identity of a single aromatic residue on a common catalyst framework, with more expansive and polarizable arenes proving optimal. Evidence is presented for a mechanism in which stabilizing cation-Pi interactions are a principal determinant of enantioselectivity.

  DOI：

  10.1021/ja101256v
• 作为产物：
  描述：

  (E)-tert-butyldimethyl((3-methyl-6-(naphthalen-1-yl)hex-3-en-1-yl)oxy)silane 在 四丁基氟化铵 作用下， 以 四氢呋喃 为溶剂， 以95%的产率得到(E)-3-methyl-6-(naphthalen-1-yl)hex-3-en-1-ol
  参考文献：
  名称：

  Enantioselective Thiourea-Catalyzed Cationic Polycyclizations

  摘要：

  A new thiourea catalyst is reported for the enantioselective cationic polycyclization of hydroxylactams. Both the yield and enantioselectivity of this transformation were found to vary strongly with the identity of a single aromatic residue on a common catalyst framework, with more expansive and polarizable arenes proving optimal. Evidence is presented for a mechanism in which stabilizing cation-Pi interactions are a principal determinant of enantioselectivity.

  DOI：

  10.1021/ja101256v