17β-formyl-4-androsten-3ξ-ol | 84416-34-2

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: 17β-formyl-4-androsten-3ξ-ol
• CAS: 84416-34-2
• 化学式: C₂₀H₃₀O₂
• 分子量: 302.457
• InChiKey: LVQPYKMHPRVCMT-RHFXQVJCSA-N

物化性质

• 沸点：
  431.8±45.0 °C(Predicted)
• 密度：
  1.10±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.13
• 重原子数：
  22.0
• 可旋转键数：
  1.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.85
• 拓扑面积：
  37.3
• 氢给体数：
  1.0
• 氢受体数：
  2.0

反应信息

• 作为产物：
  描述：

  4-pregnene-3ξ,20ξ,21-triol 在 高碘酸 作用下， 以 1,4-二氧六环 、 水 为溶剂， 反应 0.5h， 以85%的产率得到17β-formyl-4-androsten-3ξ-ol
  参考文献：
  名称：

  A new assay and solubilization procedure for steroid 17,20-lyase from rat testes

  摘要：

  We report an assay for testicular 17,20-lyase which depends on the use of [21-14C]progesterone as a substrate. The method is made possible by a simplified procedure for the synthesis of [21-14C]progesterone. A chromatographic separation of the unreacted substrate and the 2-carbon by-product on mini silica gel columns permitted a quantitative assay of the lyase activity. The lyase complex from rat testes has been solubilized by treatment with Triton CF-54 detergent. The solubilized enzyme complex catalyzes the formation of androstenedione (4-androstene-3,17-dione) from progesterone without equilibrium with added 17-hydroxyprogesterone and the solubilized enzyme complex responds to the presence of cytosol activator. Both of these characteristics are similar to the properties of the intact microsomes. Thus, solubilization with this detergent preserves the special properties of the microsome bound enzyme complex.

  DOI：

  10.1016/0039-128x(82)90133-7