(E)-N-(1,2,3,4-tetrahydronaphthalen-1-ylidene)-2-(trifluoromethyl)aniline | 137434-39-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 四氢化萘
• 英文名称: (E)-N-(1,2,3,4-tetrahydronaphthalen-1-ylidene)-2-(trifluoromethyl)aniline
• 英文别名: N-(1,2,3,4-tetrahydro-1-naphthylidene)-2-trifluoromethylaniline
• CAS: 137434-39-0
• 化学式: C₁₇H₁₄F₃N
• 分子量: 289.3
• InChiKey: KUMWZJZAWCRQMP-RCCKNPSSSA-N

物化性质

• 沸点：
  364.7±42.0 °C(Predicted)
• 密度：
  1.20±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  5.16
• 重原子数：
  21.0
• 可旋转键数：
  1.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  12.36
• 氢给体数：
  0.0
• 氢受体数：
  1.0

反应信息

• 作为反应物：
  描述：

  (E)-N-(1,2,3,4-tetrahydronaphthalen-1-ylidene)-2-(trifluoromethyl)aniline 在 盐酸 作用下， 以 甲醇 、 乙醚 、 水 为溶剂， 反应 2.5h， 生成 2-(2-aminophenyl)-1,4,5,6-tetrahydropyrimidine
  参考文献：
  名称：

  A Novel Route to 7-(Substituted Amino)-5,6-dihydrobenz[c]acridines

  摘要：

  DOI：

  10.3987/com-90-5462
• 作为产物：
  描述：

  在 盐酸 作用下， 生成 (E)-N-(1,2,3,4-tetrahydronaphthalen-1-ylidene)-2-(trifluoromethyl)aniline
  参考文献：
  名称：

  Further studies on the cyclization of aromatic azomethines ortho-substituted with a trifluoromethyl group: synthesis of 2,4-di- or 2,3,4-trisubstituted quinolines

  摘要：

  The scope and limitations of the novel synthetic route to quinolines (Strekowski et al. J. Org. Chem. 1990, 55, 4777) have been studied. A direct condensation of 2-(trifluoromethyl)aniline (1) with methyl aryl ketones, methyl heteroaryl ketones, ethyl aryl ketones, methyl vinyl ketones, 1-indanone, 1-tetralone, camphor, and cyclohexanone provides an easy access to the corresponding ketimines. An indirect one-pot preparation of dialkyl ketimines and C-alkyl-substituted amidines derived from 1, but inaccessible by the direct condensation method, is also presented. All these ketimines and amidines are cyclized in the presence of alkylamide, dialkylamide, or alkoxide bases to give a quinoline containing the base function at C-4. Analysis of byproducts of the base-mediated reactions provides strong support for the originally proposed mechanism of the quinoline formation.

  DOI：

  10.1021/jo00027a037

文献信息

• New triple-helix DNA stabilizing agents
  作者：Lucjan Strekowski、Maryam Hojjat、Ewa Wolinska、Alesia N. Parker、Ekaterina Paliakov、Tadeusz Gorecki、Farial A. Tanious、W.David Wilson

  DOI：10.1016/j.bmcl.2004.12.019

  日期：2005.2

  Several substituted quinolin-4-amines and heteroaromatic analogs were synthesized and evaluated for interaction with triplex polydA.2polydT and duplex polydA.polydT by using UV-thermal melting experiments. Excellent triple-helix DNA ligands with high affinity toward T.A.T triplets and triple/duplex selectivity were designed through a rational approach.

  合成了几种取代的喹啉-4-胺和杂芳族类似物，并通过紫外-热熔融实验评估了其与三链体polydA.2polydT和双链体polydA.polydT的相互作用。通过合理的方法设计了对TAT三联体具有高亲和力和三重/双重选择性的优秀三重螺旋DNA配体。
• Cosmetic and personal care compositions
  申请人：Unilever Home & Personal Care USA, Division of Conopco, Inc.

  公开号：US20020176834A1

  公开（公告）日：2002-11-28

  Cosmetic or personal care compositions comprise: a hair styling polymer having one or more groups selected from acidic functional groups, anionic groups derived from the acidic functional groups or a mixture of said groups; a partially or fully fluorinated compound having one or more groups selected from amino groups, acid salts of the amino groups or a mixture of said groups, wherein the partially or fully fluorinated compound comprises an aromatic ring; and a cosmetically acceptable diluent or carrier. The compositions are particularly effective under high humidity conditions.

  化妆品或个人护理组合物包括：具有一个或多个基团的头发定型聚合物，这些基团选自酸性官能团、酸性官能团衍生的阴离子基团或上述基团的混合物；具有一个或多个基团的部分或完全氟化化合物，这些基团选自氨基基团、氨基基团的酸式盐或上述基团的混合物，其中部分或完全氟化化合物包含一个芳香环；以及化妆品可接受的稀释剂或载体。这些组合物在高湿度条件下尤其有效。
• STREKOWSKI, LUCJAN;WYDRA, ROMAN L.;HARDEN, DONALD B.;HONKAN, VIDYA A., HETEROCYCLES, 31,(1990) N, C. 1565-1569
  作者：STREKOWSKI, LUCJAN、WYDRA, ROMAN L.、HARDEN, DONALD B.、HONKAN, VIDYA A.

  DOI：——

  日期：——
• US6653353B2
  申请人：——

  公开号：US6653353B2

  公开（公告）日：2003-11-25