N-[4-({(2R)-1-hydroxy-3-[(4-methylbenzyl)thio]propan-2-yl}carbamoyl)phenyl]-1,3-dihydro-2H-isoindole-2-carboxamide | 1375548-80-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 四氢化萘
• 英文名称: N-[4-({(2R)-1-hydroxy-3-[(4-methylbenzyl)thio]propan-2-yl}carbamoyl)phenyl]-1,3-dihydro-2H-isoindole-2-carboxamide
• 英文别名: isoindoline-2-carbonyl-4Abz-Cys(Mbzl)(Mbzl)-ol；N-[4-[[(2R)-1-hydroxy-3-[(4-methylphenyl)methylsulfanyl]propan-2-yl]carbamoyl]phenyl]-1,3-dihydroisoindole-2-carboxamide
• CAS: 1375548-80-3
• 化学式: C₂₇H₂₉N₃O₃S
• 分子量: 475.612
• InChiKey: XOEVTGZEFFYXAD-RUZDIDTESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  34
• 可旋转键数：
  8
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  107
• 氢给体数：
  3
• 氢受体数：
  4

文献信息

• NAMPT AND ROCK INHIBITORS
  申请人：Curtin Michael L.

  公开号：US20120122842A1

  公开（公告）日：2012-05-17

  Disclosed are compounds which inhibit the activity of NAMPT, compositions containing the compounds and methods of treating diseases during which NAMPT is expressed. Disclosed are compounds which inhibit the activity of ROCK, compositions containing the compounds and methods of treating diseases during which ROCK is expressed.

  公开了一种抑制NAMPT活性的化合物，包含该化合物的组合物和治疗NAMPT表达疾病的方法。公开了一种抑制ROCK活性的化合物，包含该化合物的组合物和治疗ROCK表达疾病的方法。
• Nampt and Rock Inhibitors
  申请人：AbbVie Inc.

  公开号：US20160031880A1

  公开（公告）日：2016-02-04

  Disclosed are compounds which inhibit the activity of NAMPT, compositions containing the compounds and methods of treating diseases during which NAMPT is expressed. Disclosed are compounds which inhibit the activity of ROCK, compositions containing the compounds and methods of treating diseases during which ROCK is expressed.

  本发明涉及抑制NAMPT活性的化合物、含有该化合物的组合物以及治疗表达NAMPT的疾病的方法。本发明还涉及抑制ROCK活性的化合物、含有该化合物的组合物以及治疗表达ROCK的疾病的方法。
• NAMPT and ROCK inhibitors
  申请人：AbbVie Inc.

  公开号：US10093624B2

  公开（公告）日：2018-10-09

  Disclosed are isoindoline carboxamide, dihydropyrrolopyridine carboxamide, and dihydropyrrolopyrimidine carboxamide compounds which inhibit the activity of NAMPT, compositions containing the compounds and methods of treating diseases during which NAMPT is expressed. Disclosed are isoindoline carboxamide, dihydropyrrolopyridine carboxamide, and dihydropyrrolopyrimidine carboxamide compounds which inhibit the activity of ROCK, compositions containing the compounds and methods of treating diseases during which ROCK is expressed.

  公开了抑制NAMPT活性的异吲哚啉甲酰胺、二氢吡咯并吡啶甲酰胺和二氢吡咯并嘧啶甲酰胺化合物、含有这些化合物的组合物以及治疗NAMPT表达的疾病的方法。公开了抑制 ROCK 活性的异吲哚啉甲酰胺、二氢吡咯并嘧啶甲酰胺和二氢吡咯并嘧啶甲酰胺化合物、含有这些化合物的组合物以及治疗表达 ROCK 的疾病的方法。
• US9302989B2
  申请人：——

  公开号：US9302989B2

  公开（公告）日：2016-04-05
• [EN] NAMPT AND ROCK INHIBITORS<br/>[FR] INHIBITEURS DE NAMPT ET ROCK
  申请人：ABBOTT LAB

  公开号：WO2012067965A1

  公开（公告）日：2012-05-24

  Disclosed are compounds of formula (1c) which inhibit the activity of NAMPT, compositions containing the compounds and methods of treating diseases during which NAMPT is expressed. Disclosed are compounds which inhibit the activity of ROCK, compositions containing the compounds and methods of treating diseases during which ROCK is expressed.