[U-14C]环氧乙烷 | 54299-16-0

• 分子结构分类: 无机化合物 - 均质非金属化合物 - 均质其他非金属化合物
• 中文名称: [U-14C]环氧乙烷
• 英文名称: ethylene oxide
• 英文别名: [U-¹⁴C]ethylene oxide；[1,2-14C]ethylene oxide；[14C2]ethylene oxide；Ethylenoxid-14C；(2,3-14C2)oxirane
• CAS: 54299-16-0
• 化学式: C₂H₄O
• 分子量: 48.0312
• InChiKey: IAYPIBMASNFSPL-XPULMUKRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.02
• 重原子数：
  3.0
• 可旋转键数：
  0.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  12.53
• 氢给体数：
  0.0
• 氢受体数：
  1.0

反应信息

• 作为反应物：
  描述：

  [U-14C]环氧乙烷 、 N-乙酰基-DL-组织氨基酸 以 盐酸 为溶剂， 反应 90.0h， 生成
  参考文献：
  名称：

  Calleman, Carl Johan; Poirier, Veronique, Acta chemica Scandinavica. Series B: Organic chemistry and biochemistry, 1983, vol. 37, # 9, p. 809 - 816

  摘要：

  DOI：
• 作为产物：
  描述：

  1-14C-2-Chlorethanol 、 氢氧化钾 以90%的产率得到
  参考文献：
  名称：

  BOGUSZEWSKI C.; UNVERRICHT A.; SCHUETTE H. R., Z. CHEM., 1979, 19, NO 10, 375-376

  摘要：

  DOI：

文献信息

• Synthesis and pharmacokinetic profile of a quaternary ammonium derivative of chlorambucil, a potential anticancer drug for the chemotherapy of chondrosarcoma
  作者：Maryse Rapp、Isabelle Giraud、Jean-Claude Maurizis、Jean-Claude Madelmont

  DOI：10.1016/j.bmc.2003.09.006

  日期：2003.11

  As a part of our targeting program based on the affinity of the quaternary ammonium moiety for cartilage, our objective was to develop more selective anticancer drugs towards chondrosarcoma that would concentrate in this malignant cartilaginous tissue and so improve the therapeutic index through a reduction of side effects. For this purpose we have synthesized and labeled with C-14 a quaternary ammonium (QA) derivative of chlorambucil. Biological studies performed in rats showed that [C-14]-CQA and [C-14]-chlorambucil exhibited different pharmacokinetic profiles. The blood elimination of [C-14]-CQA was faster than that of parent compound. [C-14]-CQA was principally excreted by the fecal way. However, until 15 min after administration, levels of radioactivity were measured in cartilaginous tissues of rats given [C-14]-CQA which was not the case for the rats which had received [C-14]-chlorambucil. Although rates of radioactivity were quantified only during 15 min, these results prove that the functionalization of chlorambucil by a quaternary ammonium group allows the molecule to be carried selectively to cartilaginous tissues. (C) 2003 Elsevier Ltd. All rights reserved.
• Poirier, Veronique; Calleman, Carl Johan, Acta chemica Scandinavica. Series B: Organic chemistry and biochemistry, 1983, vol. 37, # 9, p. 817 - 822
  作者：Poirier, Veronique、Calleman, Carl Johan

  DOI：——

  日期：——
• MISTRY, JEHANGIR S.;ABRAHAM, DONALD J.;HANIN, ISRAEL, J. LABELL. COMPOUNDS AND RADIOPHARM., 27,(1989) N0, C. 1105-1114
  作者：MISTRY, JEHANGIR S.、ABRAHAM, DONALD J.、HANIN, ISRAEL

  DOI：——

  日期：——
• ARIMA, HIDEKI;TAMAZAWA, KAZUHARU, J. LABELLED COMPOUNDS AND RADIOPHARM., 1983, 20, N 7, 803-811
  作者：ARIMA, HIDEKI、TAMAZAWA, KAZUHARU

  DOI：——

  日期：——
• HAYS S. J., J. LABELLED COMPOUNDS AND RADIOPHARM., 24,(1987) N 4, 351-360
  作者：HAYS S. J.

  DOI：——

  日期：——