1-(1,4-Cyclohexadienyl)-2-methylaminopropane | 855312-71-9

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 1-(1,4-Cyclohexadienyl)-2-methylaminopropane
• 英文别名: 1-cyclohexa-1,4-dien-1-yl-N-methylpropan-2-amine
• CAS: 855312-71-9
• 化学式: C₁₀H₁₇N
• 分子量: 151.25
• InChiKey: DIMNLUIMZVXIKS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2
• 重原子数：
  11
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  12
• 氢给体数：
  1
• 氢受体数：
  1

文献信息

• MUTAGENIC NUCLEOSIDE ANALOGS AND USES THEREOF
  申请人：Massachusetts Institute of Technology

  公开号：US20160222050A1

  公开（公告）日：2016-08-04

  The present disclosure provides nucleoside analogs of Formula (I) or (II). The nucleoside analogs are expected to show multiple tautomerism and may increase the mutation of an RNA and/or DNA (be mutagenic) of a virus or cancer cell. The multiple tautomerism and mutagenesis of the nucleoside analogs may be adjusted by substituting the nucleoside analogs with one or more electron-donating groups and/or electron-withdrawing groups to increase or decrease the pK a (e.g., to a pK a between 5.5 or 8.5). The present disclosure also provides pharmaceutical compositions and kits including the nucleoside analogs and methods of treating a viral infection (e.g., influenza, HIV infection, or hepatitis) or cancer using the nucleoside analogs, pharmaceutical compositions, or kits.
• US9714265B2
  申请人：——

  公开号：US9714265B2

  公开（公告）日：2017-07-25