N-(3-piperidin-1-ylpropyl)-5H-spiro[benzo[h]quinazoline-6,4-piperidin]-2-amine | 1234353-58-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: N-(3-piperidin-1-ylpropyl)-5H-spiro[benzo[h]quinazoline-6,4-piperidin]-2-amine
• 英文别名: N-(3-piperidin-1-ylpropyl)spiro[5H-benzo[h]quinazoline-6,4'-piperidine]-2-amine
• CAS: 1234353-58-2
• 化学式: C₂₄H₃₃N₅
• 分子量: 391.56
• InChiKey: QUKNKLYIXMXYJQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  29
• 可旋转键数：
  5
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.58
• 拓扑面积：
  53.1
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• [EN] RSV POLYMERASE INHIBITORS<br/>[FR] INHIBITEURS POLYMERASE RSV
  申请人：BOEHRINGER INGELHEIM CA LTD

  公开号：WO2005042530A1

  公开（公告）日：2005-05-12

  Compounds or enantiomers of formula (I) or a salt thereof: wherein R1, R2, R3, R4 and R5 are as defined herein, are useful for the manufacture of a medicament for the treatment or prevention of respiratory syncytial virus infection in a mammal.

  化合物或式(I)的对映体或盐：其中R1、R2、R3、R4和R5如本文所定义，可用于制造用于治疗或预防哺乳动物呼吸道合胞病毒感染的药物。
• SUBSTITUTED 5,6-DIHYDRO-6-PHENYLBENZO[F]ISOQUINOLIN-2-AMINE COMPOUNDS
  申请人：Ali Syed M.

  公开号：US20100239525A1

  公开（公告）日：2010-09-23

  The present invention relates to substituted 5,6-dihydro-6-phenylbenzo[f]isoquinolin-2-amine compounds and methods of synthesizing these compounds. The present invention also relates to pharmaceutical compositions containing substituted 5,6-dihydro-6-phenylbenzo[f]isoquinolin-2-amine compounds and methods of treating cell proliferative disorders, such as cancer, by administering these compounds and pharmaceutical compositions to subjects in need thereof.

  本发明涉及取代的5,6-二氢-6-苯基苯并[f]异喹啉-2-胺化合物及其合成方法。本发明还涉及含有取代的5,6-二氢-6-苯基苯并[f]异喹啉-2-胺化合物的药物组合物，以及通过将这些化合物和药物组合物用于需要治疗细胞增殖性疾病的受试者来治疗癌症等细胞增殖性疾病的方法。
• US8357694B2
  申请人：——

  公开号：US8357694B2

  公开（公告）日：2013-01-22
• [EN] SPIRO-CONTAINING COMPOUNDS AND COMPOSITIONS AS MODULATORS OF STEROID HORMONE NUCLEAR RECEPTORS<br/>[FR] COMPOSES ET COMPOSITIONS SPIRO EN TANT QUE MODULATEURS DES RECEPTEURS NUCLEAIRES DES HORMONES STEROIDES
  申请人：IRM LLC

  公开号：WO2006104594A2

  公开（公告）日：2006-10-05

  [EN] Described herein are compounds that have a spiro structural feature. Also described herein are methods for making such compounds, methods for using such compounds to modulate the activity of steroid hormone nuclear receptors, and pharmaceutical compositions and medicaments comprising such compounds. Also described herein are methods of using such compounds, pharmaceutical compositions and medicaments to treat and/or prevent diseases or conditions associated with the activity of steroid hormone nuclear receptors.
  [FR] La présente invention a trait à des composés présentant une élément structurel spiro. L'invention a également trait à des procédés pour la production de tels composés, à des procédés d'utilisation de tels composés pour la modulation de l'activité des récepteurs nucléaires des hormones stéroïdes, et à des compositions pharmaceutiques et des médicaments comportant de tels composés. L'invention a trait en outre à des procédés d'utilisation de tels composés, compositions pharmaceutiques et médicaments pour le traitement et/ou la prévention de maladies ou conditions associées à l'activité des récepteurs nucléaires des hormones stéroïdes.
• [EN] SUBSTITUTED 5,6-DIHYDRO-6-PHENYLBENZO[F] ISOQUINOLIN-2-AMINE COMPOUNDS<br/>[FR] COMPOSÉS DE 5,6-DIHYDRO-6-PHÉNYLBENZO[F]ISOQUINOLÉINE-2-AMINES SUBSTITUÉES
  申请人：ARQULE INC

  公开号：WO2010078421A1

  公开（公告）日：2010-07-08

  The present invention relates to substituted 5,6-dihydro-6- phenylbenzo[f]isoquinolin-2-amine compounds and methods of synthesizing these compounds. The present invention also relates to pharmaceutical compositions containing substituted 5,6-dihydro-6-phenylbenzo[f]isoquinolin-2-amine compounds and methods of treating cell proliferative disorders, such as cancer, by administering these compounds and pharmaceutical compositions to subjects in need thereof.