| 1440970-26-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• CAS: 1440970-26-2
• 化学式: C₄₀H₄₂N₂O₇S₂
• 分子量: 726.915
• InChiKey: QLCXPPKPOWYWOZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.6
• 重原子数：
  51.0
• 可旋转键数：
  12.0
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  140.65
• 氢给体数：
  1.0
• 氢受体数：
  7.0

反应信息

• 作为产物：
  描述：

  萘酚 在 乌洛托品 、 sodium acetate 作用下， 以 乙酸酐 为溶剂， 反应 1.0h， 生成
  参考文献：
  名称：

  New repertoire of ‘donor-two-acceptor’ NIR fluorogenic dyes

  摘要：

  Dye molecules with various fluorescent wavelengths are widely used for diagnostic and optical imaging applications. Accordingly, there is a constant demand for fluorogenic dyes with new properties. We have recently developed a novel strategy for the design of long-wavelength fluorescent dyes with a turn-ON option. The design is based on a donor-two-acceptor pi-electron system that can undergo an internal charge transfer to form a new fluorochrome with an extended pi-conjugated system. Here, we describe a series of such dyes based on two novel latent donors, naphthol and hydroxycoumarin. One of the dyes has showed excellent near-infrared fluorescent characteristics and specifically was demonstrated as a mitochondrial imaging reagent in live cells. This unique strategy for fluorogenic dye design has opened new doors for further near-infrared fluorescence probe discovery. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmc.2013.02.049

文献信息

• Synthesis and evaluation of new NIR-fluorescent probes for cathepsin B: ICT versus FRET as a turn-ON mode-of-action
  作者：Einat Kisin-Finfer、Shiran Ferber、Rachel Blau、Ronit Satchi-Fainaro、Doron Shabat

  DOI：10.1016/j.bmcl.2014.04.022

  日期：2014.6

  applications. The expression or activity of specific enzymes including proteases can be monitored by cutting edge molecular imaging techniques. Cathepsin B plays key roles in tumor progression via controlled degradation of extracellular matrix. Consequently, this protease has been attracting significant attention in cancer research, and many imaging probes targeting its activity have been developed. Here

  近年来，在面向生物学和生物医学应用的分子成像设计和研究中取得了巨大进展。包括蛋白酶在内的特定酶的表达或活性可以通过尖端的分子成像技术进行监测。组织蛋白酶B通过控制细胞外基质的降解在肿瘤进展中起关键作用。因此，该蛋白酶已在癌症研究中引起了广泛的关注，并且已经开发了许多靶向其活性的成像探针。在这里，我们描述了两种新颖的近红外（NIR）荧光探针的设计，合成和评估，用于检测具有不同开启机制的组织蛋白酶B活性。一种探针基于供体两受体π电子染料系统的ICT激活机制，另一个是基于由荧光染料和淬灭剂获得的FRET机理。两种探针在被组织蛋白酶B切割后均显示出显着的荧光开启响应。ICT探针在关闭状态下的NIR荧光显着低于基于FRET的探针。这种效果导致更高的信噪比，从而提高了灵敏度和更好的图像对比度。