1-{3,3,3-trifluoro-2-[5-(4-fluorophenyl)-[1,3,4]oxadiazol-2-ylmethyl]-propyl}-3-(3-trifluoromethyl-phenyl)-piperidine hydrochloride | 1609575-50-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 哌啶类
• 英文名称: 1-{3,3,3-trifluoro-2-[5-(4-fluorophenyl)-[1,3,4]oxadiazol-2-ylmethyl]-propyl}-3-(3-trifluoromethyl-phenyl)-piperidine hydrochloride
• 英文别名: 2-(4-Fluorophenyl)-5-[3,3,3-trifluoro-2-[[3-[3-(trifluoromethyl)phenyl]piperidin-1-yl]methyl]propyl]-1,3,4-oxadiazole;hydrochloride
• CAS: 1609575-50-9
• 化学式: C₂₄H₂₂F₇N₃O*ClH
• 分子量: 537.908
• InChiKey: SSLHYNCRGLCTFJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.92
• 重原子数：
  36
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  42.2
• 氢给体数：
  1
• 氢受体数：
  11

文献信息

• [EN] [3-HETEROARYL-2-TRIFLUOROMETHYL-PROPYL]-PIPERIDIN-1-YLE OR -MORPHOLIN-4-YLE COMPOUNDS AS TRPA1 ANTAGONISTS FOR THE TREATMENT OF RESPIRATORY DISEASES<br/>[FR] COMPOSÉS [3-HÉTÉROARYL-2-TRIFLUOROMÉTHYL-PROPYL]-PIPÉRIDIN-1-YLE OU -MORPHOLIN-4-YLE EN TANT QU'ANTAGONISTES DE TRPA1 POUR LE TRAITEMENT DE MALADIES RESPIRATOIRES
  申请人：HOFFMANN LA ROCHE

  公开号：WO2014072325A1

  公开（公告）日：2014-05-15

  The invention is concerned with the compounds of formula (I) and pharmaceutically acceptable salts thereof. In addition, the present invention relates to methods of manufacturing and using the compounds of formula (I) as well as pharmaceutical compositions containing such compounds. The compounds of formula (I) are antagonists of the TRPA1 channel and may be useful in treating inflammatory diseases and disorders associated with that channel.

  本发明涉及公式（I）的化合物及其药用可接受的盐。此外，本发明涉及制造和使用公式（I）化合物的方法，以及含有这种化合物的药物组合物。公式（I）化合物是TRPA1通道的拮抗剂，可能对治疗与该通道相关的炎症性疾病和紊乱有用。
• SUBSTITUTED CARBAMATE COMPOUNDS
  申请人：Hoffmann-La Roche Inc.

  公开号：US20150239873A1

  公开（公告）日：2015-08-27

  The invention is concerned with the compounds of formula (I): and pharmaceutically acceptable salts thereof. In addition, the present invention relates to methods of manufacturing and using the compounds of formula (I) as well as pharmaceutical compositions containing such compounds. The compounds of formula (I) are antagonists of the TRPA1 channel and may be useful in treating inflammatory diseases and disorders associated with that channel.

  本发明涉及公式(I)的化合物及其药学上可接受的盐。此外，本发明还涉及制造和使用公式(I)化合物的方法，以及包含这些化合物的药物组合物。公式(I)化合物是TRPA1通道的拮抗剂，可能对治疗与该通道相关的炎症性疾病和紊乱有用。
• [3-HETEROARYL-2-TRIFLUOROMETHYL-PROPYL]-PIPERIDIN-1-YLE OR -MORPHOLIN-4-YLE COMPOUNDS AS TRPA1 ANTAGONISTS FOR THE TREATMENT OF RESPIRATORY DISEASES
  申请人：F.Hoffmann-La Roche AG

  公开号：EP2917208A1

  公开（公告）日：2015-09-16
• US9388172B2
  申请人：——

  公开号：US9388172B2

  公开（公告）日：2016-07-12