2-Naphthalen-2-yl-3-[4-(trifluoromethyl)phenyl]quinoxaline | 1334220-56-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 2-Naphthalen-2-yl-3-[4-(trifluoromethyl)phenyl]quinoxaline
• 英文别名: 2-naphthalen-2-yl-3-[4-(trifluoromethyl)phenyl]quinoxaline
• CAS: 1334220-56-2
• 化学式: C₂₅H₁₅F₃N₂
• 分子量: 400.403
• InChiKey: HABVEHLZMDCKCX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.7
• 重原子数：
  30
• 可旋转键数：
  2
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.04
• 拓扑面积：
  25.8
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  tert-butyl N-[2-[[1-naphthalen-2-yl-2-oxo-2-[4-(trifluoromethyl)phenyl]ethyl]amino]phenyl]carbamate 在 三氟乙酸 作用下， 以 二氯甲烷 为溶剂， 反应 18.0h， 以91%的产率得到2-Naphthalen-2-yl-3-[4-(trifluoromethyl)phenyl]quinoxaline
  参考文献：
  名称：

  A novel route to synthesize libraries of quinoxalines via Petasis methodology in two synthetic operations

  摘要：

  This Letter reveals an innovative and facile procedure to prepare quinoxalines in two synthetic steps. The microwave assisted Petasis reaction is followed by the acid mediated unmasking of an internal amino nucleophile, cyclodehydration and oxidation to give collections of quinoxalines in good to excellent yields. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2011.06.115

文献信息

• A novel route to synthesize libraries of quinoxalines via Petasis methodology in two synthetic operations
  作者：Muhammad Ayaz、Justin Dietrich、Christopher Hulme

  DOI：10.1016/j.tetlet.2011.06.115

  日期：2011.9

  This Letter reveals an innovative and facile procedure to prepare quinoxalines in two synthetic steps. The microwave assisted Petasis reaction is followed by the acid mediated unmasking of an internal amino nucleophile, cyclodehydration and oxidation to give collections of quinoxalines in good to excellent yields. (C) 2011 Elsevier Ltd. All rights reserved.