2-(4-Fluorophenyl)-3-(4-methylphenyl)quinoxaline | 1334220-52-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氮杂萘
• 英文名称: 2-(4-Fluorophenyl)-3-(4-methylphenyl)quinoxaline
• 英文别名: 2-(4-fluorophenyl)-3-(4-methylphenyl)quinoxaline
• CAS: 1334220-52-8
• 化学式: C₂₁H₁₅FN₂
• 分子量: 314.362
• InChiKey: QMOLELCFWSXZLD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  24
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  25.8
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  tert-butyl N-[2-[[2-(4-fluorophenyl)-1-(4-methylphenyl)-2-oxoethyl]amino]phenyl]carbamate 在 三氟乙酸 作用下， 以 二氯甲烷 为溶剂， 反应 18.0h， 以98%的产率得到2-(4-Fluorophenyl)-3-(4-methylphenyl)quinoxaline
  参考文献：
  名称：

  A novel route to synthesize libraries of quinoxalines via Petasis methodology in two synthetic operations

  摘要：

  This Letter reveals an innovative and facile procedure to prepare quinoxalines in two synthetic steps. The microwave assisted Petasis reaction is followed by the acid mediated unmasking of an internal amino nucleophile, cyclodehydration and oxidation to give collections of quinoxalines in good to excellent yields. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2011.06.115

文献信息

• Visible-Light-Induced CC Bond Cleavage of Enaminones for the Synthesis of 1,2-Diketones and Quinoxalines in Sustainable Medium
  作者：Shuo Cao、Shanshan Zhong、Luoting Xin、Jie-Ping Wan、Chengping Wen

  DOI：10.1002/cctc.201500139

  日期：2015.5.4

  The CC double bond cleavage of enaminones has been realized under ambient conditions through visible‐light catalysis in the presence of Rose Bengal, which leads to the synthesis of a class of 1,2‐diketones without using any metal catalyst. In addition, the one‐pot synthesis of quinoxalines has also been achieved under identical photocatalytic conditions by making use of the in situ generated 1,2‐diketones

  在存在玫瑰红的情况下，通过可见光催化在环境条件下实现了烯胺酮的CC双键裂解，这导致无需使用任何金属催化剂即可合成一类1,2-二酮。此外，利用原位生成的1,2-二酮作为中间体，在相同的光催化条件下也可以完成一锅合成喹喔啉的合成。
• Light-emitting element, light-emitting device, electronic device, and quinoxaline derivative
  申请人：Semiconductor Energy Laboratory Co., Ltd.

  公开号：EP2573075A1

  公开（公告）日：2013-03-27

  The present invention provides quinoxaline derivatives having an electron-trapping property and light-emitting elements, light-emitting devices and electronic devices comprising the same. The light-emitting element according to the present invention comprises a quinoxaline derivative as an organic compound. Advantageously, the present invention provides light-emitting elements having long lifetime, and light-emitting devices and electronic devices having long lifetime.

  本发明提供了具有电子捕获特性的喹喔啉衍生物和发光元件、发光器件以及包含这些元件的电子器件。根据本发明，发光元件包括作为有机化合物的喹喔啉衍生物。有利的是，本发明提供了具有长寿命的发光元件，以及具有长寿命的发光器件和电子设备。
• POROUS CYCLODEXTRIN POLYMERIC MATERIALS AND METHODS OF MAKING AND USING SAME
  申请人：Cornell University

  公开号：US20170173560A1

  公开（公告）日：2017-06-22

  A nucleophilic substitution reaction to crosslink cyclodextrin (CD) polymer with rigid aromatic groups, providing a high surface area, mesoporous CD-containing polymers (P-CDPs). The P-CDPs can be used for removing organic contaminants from water. By encapsulating pollutants to form well-defined host-guest complexes with complementary selectivities to activated carbon (AC) sorbents. The P-CDPs can rapidly sequester pharmaceuticals, pesticides, and other organic micropollutants, achieving equilibrium binding capacity in seconds with adsorption rate constants 15-200 times greater than ACs and nonporous CD sorbents. The CD polymer can be regenerated several times, through a room temperature washing procedure, with no loss in performance.
• US9855545B2
  申请人：——

  公开号：US9855545B2

  公开（公告）日：2018-01-02
• A novel route to synthesize libraries of quinoxalines via Petasis methodology in two synthetic operations
  作者：Muhammad Ayaz、Justin Dietrich、Christopher Hulme

  DOI：10.1016/j.tetlet.2011.06.115

  日期：2011.9

  This Letter reveals an innovative and facile procedure to prepare quinoxalines in two synthetic steps. The microwave assisted Petasis reaction is followed by the acid mediated unmasking of an internal amino nucleophile, cyclodehydration and oxidation to give collections of quinoxalines in good to excellent yields. (C) 2011 Elsevier Ltd. All rights reserved.