NO-budesonide | 571186-52-2

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: NO-budesonide
• 英文别名: [2-[(1S,2S,4R,8S,9S,11S,12S,13R)-11-hydroxy-9,13-dimethyl-16-oxo-6-propyl-5,7-dioxapentacyclo[10.8.0.02,9.04,8.013,18]icosa-14,17-dien-8-yl]-2-oxoethyl] 4-(nitrooxymethyl)benzoate
• CAS: 571186-52-2
• 化学式: C33H39NO10
• 分子量: 609.7
• InChiKey: SYBXBIHWNMPDPT-PBCNJCODSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  44
• 可旋转键数：
  9
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.61
• 拓扑面积：
  154
• 氢给体数：
  1
• 氢受体数：
  10

文献信息

• Combination of nitroderivatized steroid and bronchodilator for treating respiratory disease
  申请人：Renzi Paolo

  公开号：US20090087425A1

  公开（公告）日：2009-04-02

  There is provided a pharmaceutical composition for treating respiratory disease comprising an NO-donating steroid and at least one bronchodilator. Also provided is a method for treating respiratory diseases associated with inflammation comprising administering an NO-donating steroid with at least one bronchodilator. Method of use of the combination of an NO-donating compound, and a steroid with at least one bronchodilator for treating respiratory disease is also provided.