(2R)-2-(acetyloxy)-4-({1-[(2-hydroxy-1-naphthyl)methyl]-2-naphthyl}oxy)-N,N,N-trimethyl-4-oxo-1-butanaminium chloride | 385390-48-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 英文名称: (2R)-2-(acetyloxy)-4-({1-[(2-hydroxy-1-naphthyl)methyl]-2-naphthyl}oxy)-N,N,N-trimethyl-4-oxo-1-butanaminium chloride
• 英文别名: [(2R)-2-acetyloxy-4-[1-[(2-hydroxynaphthalen-1-yl)methyl]naphthalen-2-yl]oxy-4-oxobutyl]-trimethylazanium;chloride
• CAS: 385390-48-7
• 化学式: C₃₀H₃₂NO₅*Cl
• 分子量: 522.041
• InChiKey: QRLJJZVAHNQKDW-GNAFDRTKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.23
• 重原子数：
  37
• 可旋转键数：
  10
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  72.8
• 氢给体数：
  1
• 氢受体数：
  6

反应信息

• 作为产物：
  描述：

  、 acetyl L-carnitine chloride 、 1,1-亚甲基-2-萘酚 在 乙醚 、 crude product 、 silica 、 methanol-dichloromethane 作用下， 以 乙腈 为溶剂， 反应 16.0h， 以to give 2 g (0.0038 mol) of (2R)-2-(acetyloxy)-4-({1-[(2-hydroxy-1-naphthyl)methyl]-2-naphthyl}oxy)-N,N,N-trimethyl-4-oxo-1-butanaminium chloride (ST1745)的产率得到(2R)-2-(acetyloxy)-4-({1-[(2-hydroxy-1-naphthyl)methyl]-2-naphthyl}oxy)-N,N,N-trimethyl-4-oxo-1-butanaminium chloride
  参考文献：
  名称：

  Use of pamoic acid or one of its derivatives, or one of its analogues, for the preparation of a medicament for the treatment of diseases characterised by deposits of amyloid aggregates

  摘要：

  Pamoic acid或其式(I)的衍生物用于治疗由淀粉样蛋白聚集物沉积所特征的疾病。

  公开号：

  US20080293812A1

文献信息

• Use of pamoic acid or one of its derivatives, or one of its analogues , for the preparation of a medicament for the treatment of diseases characterised by deposits of amyloid aggregates
  申请人：——

  公开号：US20040029963A1

  公开（公告）日：2004-02-12

  The use of pamoic acid or of one of its derivatives is described with general formula (I), in which groups R1 and R5 are as indicated in the description, or of one of their pharmaceutically acceptable salts, for the preparation of a medicament for the treatment of diseases characterised by deposits of amyloid aggregates. 1

  使用苯酚甲酸或其衍生物之一的通用公式（I）来描述，其中R1和R5基团如描述中所示，或其药学上可接受的盐之一，用于制备治疗由淀粉样聚集物沉积引起的疾病的药物。
• USE OF PAMOIC ACID OR ONE OF ITS DERIVATIVES, OR ONE OF ITS ANALOGUES, FOR THE PREPARATION OF A MEDICAMENT FOR THE TREATMENT OF DISEASES CHARACTERISED BY DEPOSITS OF AMYLOID AGGREGATES
  申请人：SIGMA-TAU IndustrieFarmaceutiche Riunite S.p.A.

  公开号：EP1301463A1

  公开（公告）日：2003-04-16
• [EN] USE OF PAMOIC ACID OR ONE OF ITS DERIVATIVES, OR ONE OF ITS ANALOGUES, FOR THE PREPARATION OF A MEDICAMENT FOR THE TREATMENT OF DISEASES CHARACTERISED BY DEPOSITS OF AMYLOID AGGREGATES<br/>[FR] UTILISATION DE L'ACIDE PAMOIQUE OU DE L'UN DE SES DERIVES OU ANALOGUES POUR LA PREPARATION D'UN MEDICAMENT DESTINE AU TRAITEMENT DES MALADIES CARACTERISEES PAR DES DEPOTS D'AGREGATS AMYLOIDES
  申请人：SIGMA TAU IND FARMACEUTI

  公开号：WO2002000603A1

  公开（公告）日：2002-01-03

  The use of pamoic acid or of one of its derivatives is described with general formula (I), in which groups R1 and R5 are as indicated in the description, or of one of their pharmaceutically acceptable salts, for the preparation of a medicament for the treatment of diseases characterised by deposits of amyloid aggregates.