betamethasome-3-(O-carboxymethy)oxime | 61600-49-5

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: betamethasome-3-(O-carboxymethy)oxime
• CAS: 61600-49-5；88378-32-9
• 化学式: C₂₄H₃₂FNO₇
• 分子量: 465.519
• InChiKey: TZIQAVQWZDRJBY-PGXNALDPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.78
• 重原子数：
  33.0
• 可旋转键数：
  5.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  136.65
• 氢给体数：
  4.0
• 氢受体数：
  7.0

反应信息

• 作为产物：
  描述：

  倍他米松 、 羧甲基羟胺半盐酸盐 在 吡啶 作用下， 以 乙醇 为溶剂， 反应 8.0h， 以55%的产率得到betamethasome-3-(O-carboxymethy)oxime
  参考文献：
  名称：

  An enzyme immunoassay for plasma betamethasone

  摘要：

  A sensitive enzyme immunoassay for plasma betamethasone was developed using betamethasone-3-(O-carboxymethyl)oxime-beta-D-galactosidase conjugate as a labelled antigen and 4-methylumbelliferyl-beta-D-galactoside as a fluorescence substrate. The performances of the enzyme immunoassay were compared with that of a radioimmunoassay using 3H-betamethasone and the same antiserum. The minimal detectable level for the enzyme immunoassay was 0.15 pg/tube or 0.15 ng/ml of plasma, which was remarkably more sensitive than the radioimmunoassay level of 10 pg/tube or 2 ng/ml of plasma. The specificity was sufficient, in particular, the cross reactivity of cortisol as 0.008%. However, the precision of the enzyme immunoassay was inferior to that of the radioimmunoassay.

  DOI：

  10.1016/s0039-128x(81)90284-1