N-cyclopropyl-hydroxylamine | 435270-09-0

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N-cyclopropyl-hydroxylamine
• 英文别名: N-cyclopropylhydroxylamine
• CAS: 435270-09-0
• 化学式: C₃H₇NO
• 分子量: 73.0947
• InChiKey: ATLZOHJWRFQKDI-UHFFFAOYSA-N

物化性质

• 沸点：
  144.0±23.0 °C(Predicted)
• 密度：
  1.12±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -0.1
• 重原子数：
  5
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  32.3
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  6-methoxy-2,5,7,8-tetramethylchroman-2-carbaldehyde 、 N-cyclopropyl-hydroxylamine 以 乙醇 为溶剂， 反应 3.0h， 以80%的产率得到N-cyclopropyl-1-(6-methoxy-2,5,7,8-tetramethyl-3,4-dihydrochromen-2-yl)methanimine oxide
  参考文献：
  名称：

  Nitrone derivatives of trolox as neuroprotective agents

  摘要：

  Synthesis of nitrone derivatives of trolox is described. Their biological evaluation was performed in vitro for scavenging different free radicals, inhibiting Fe2+-induced lipid peroxidation, and in vivo in a permanent middle cerebral artery occlusion model in mice. New compounds exert pharmacological activities comparable to or better than those of trolox or nitrone-type reference compounds. (c) 2005 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2005.04.043
• 作为产物：
  描述：

  1-硝基环丙烷 在 ammonium chloride 、 锌 作用下， 以 水 为溶剂， 以65%的产率得到N-cyclopropyl-hydroxylamine
  参考文献：
  名称：

  Synthesis of C-Aryl-N-cyclopropylnitrones

  摘要：

  Synthesis of C-aryl-N-cyclopropylnitrones is described. Preparations were performed either by condensation of the appropriate aldehyde with N-cyclopropyl-hydroxylamine, or oxidation of N-substituted N-cyclopropylamines with sodium tungstate/hydrogen peroxide.

  DOI：

  10.1081/scc-120024001

文献信息

• 一类苯并噻吩类化合物及其药物组合物及应用
  申请人：中国科学院上海药物研究所

  公开号：CN111393404B

  公开（公告）日：2023-02-17

  本发明涉及一类苯并噻吩类化合物及其药物组合物及应用。具体地，本发明化合物具有式I所示结构，其中各基团和取代基的定义如说明书中所述。本发明还公开了所述化合物的制备方法及其在抗肿瘤方面的用途。
• Stammer,R. et al., Recueil des Travaux Chimiques des Pays-Bas, 1970, vol. 89, p. 169 - 174
  作者：Stammer,R. et al.

  DOI：——

  日期：——
• Nitrone derivatives of trolox as neuroprotective agents
  作者：György T. Balogh、Krisztina Vukics、Árpád Könczöl、Ágnes Kis-Varga、Anikó Gere、János Fischer

  DOI：10.1016/j.bmcl.2005.04.043

  日期：2005.6

  Synthesis of nitrone derivatives of trolox is described. Their biological evaluation was performed in vitro for scavenging different free radicals, inhibiting Fe2+-induced lipid peroxidation, and in vivo in a permanent middle cerebral artery occlusion model in mice. New compounds exert pharmacological activities comparable to or better than those of trolox or nitrone-type reference compounds. (c) 2005 Elsevier Ltd. All rights reserved.
• Synthesis of C-Aryl-N-cyclopropylnitrones
  作者：Vukics, Krisztina、Tarkanyi, Gabor、Dravecz, Ferenc、Fischer, Janos

  DOI：10.1081/scc-120024001

  日期：2003.9

  Synthesis of C-aryl-N-cyclopropylnitrones is described. Preparations were performed either by condensation of the appropriate aldehyde with N-cyclopropyl-hydroxylamine, or oxidation of N-substituted N-cyclopropylamines with sodium tungstate/hydrogen peroxide.