5’-adenosine diphosphate N1-oxide | 36703-14-7

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘌呤核苷酸
• 英文名称: 5’-adenosine diphosphate N1-oxide
• 英文别名: O^5'-trihydroxydiphosphoryl-adenosine 1-oxide；O^5'-Trihydroxydiphosphoryl-adenosin-1-oxid；Adenosin-diphosphat-1-N-oxid；1-N-Oxid-ADP
• CAS: 36703-14-7
• 化学式: C₁₀H₁₅N₅O₁₁P₂
• 分子量: 443.204
• InChiKey: OTUIETOGXMCVLW-KQYNXXCUSA-N

物化性质

• 沸点：
  962.2±75.0 °C(Predicted)
• 密度：
  2.54±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  -2.51
• 重原子数：
  28.0
• 可旋转键数：
  6.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  246.65
• 氢给体数：
  6.0
• 氢受体数：
  12.0

反应信息

• 作为产物：
  描述：

  5'-腺嘌呤核苷酸 在 双氧水 作用下， 生成 5’-adenosine diphosphate N1-oxide
  参考文献：
  名称：

  Purine N-Oxides. V. Oxides of Adenine Nucleotides¹

  摘要：

  DOI：

  10.1021/ja01516a053

文献信息

• THERAPEUTIC AGENT FOR INFLAMMATORY DISEASES, CONTAINING ADENOSINE N1-OXIDE AS AN EFFECTIVE INGREDIENT
  申请人：Kohno Keizo

  公开号：US20130165399A1

  公开（公告）日：2013-06-27

  The present invention has an object to provide an effective and safe therapeutic agent for inflammatory diseases such as sepsis, hepatitis, and inflammatory bowel disease, and solves the above object by providing a therapeutic agent for inflammatory diseases containing adenosine N1-oxide or a derivative thereof as an effective ingredient.

  本发明的目的是提供一种有效而安全的治疗剂，用于治疗炎症性疾病，如败血症、肝炎和炎症性肠病，通过提供一种含有腺苷N1-氧化物或其衍生物作为有效成分的炎症性疾病治疗剂来解决上述问题。
• ANTI-AGING EXTERNAL SKIN PREPARATION
  申请人：Hayashibara Co., Ltd.

  公开号：EP3130332A1

  公开（公告）日：2017-02-15

  The present invention aims to provide an external dermal composition for anti-ageing, which prevents or improves apparent skin problems such as age-related or senescent wrinkles, fine wrinkles, saggings, spots, etc., as well as maintaining or enhancing the skin barrier functions. The object is solved by providing an external dermal agent for anti-ageing, which contains as an effective ingredient(s) one or more members selected from the group consisting of adenosine N1-oxide 5'-phosphate, analogues thereof, and their salts.

  本发明旨在提供一种用于抗衰老的外用皮肤组合物，该组合物可预防或改善明显的皮肤问题，如与年龄有关的或衰老性皱纹、细小皱纹、疤痕、斑点等，以及保持或增强皮肤屏障功能。本发明的目的是提供一种用于抗衰老的外用皮肤制剂，该制剂含有一种或多种有效成分，这些成分选自 5'-磷酸腺苷 N1-氧化物、其类似物及其盐组成的组。
• External dermatological agent for anti-ageing
  申请人：Hayashibara Co., Ltd.

  公开号：US10071042B2

  公开（公告）日：2018-09-11

  The present invention aims to provide an external dermal composition for anti-ageing, which prevents or improves apparent skin problems such as age-related or senescent wrinkles, fine wrinkles, saggings, spots, etc., as well as maintaining or enhancing the skin barrier functions. The object is solved by providing an external dermal agent for anti-ageing, which contains as an effective ingredient(s) one or more members selected from the group consisting of adenosine N1-oxide 5′-phosphate, analogs thereof, and their salts.

  本发明的目的是提供一种用于抗衰老的外用皮肤组合物，它能防止或改善明显的皮肤问题，如与年龄有关的或衰老性皱纹、细小皱纹、疤痕、斑点等，以及保持或增强皮肤屏障功能。本发明的目的是提供一种用于抗衰老的外用皮肤制剂，该制剂含有一种或多种有效成分，这些有效成分选自由腺苷 N1-氧化物 5′-磷酸、其类似物及其盐组成的组。
• ORAL WASHING COMPOSITION FOR PREVENTING AND/OR TREATING PERIODONTAL DISEASES
  申请人：Hayashibara Co., Ltd.

  公开号：EP2801348B1

  公开（公告）日：2019-05-22
• THERAPEUTIC AGENT FOR INFLAMMATORY DISEASES CONTAINING ADENOSINE N1-OXIDE AS ACTIVE INGREDIENT
  申请人：Hayashibara Co., Ltd.

  公开号：EP2583972B1

  公开（公告）日：2018-04-18