1alpha,24S-Dihydroxyvitamin D2 | 156316-85-7

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: 1alpha,24S-Dihydroxyvitamin D2
• 英文别名: (1R,3S,5Z)-5-[(2E)-2-[(1R,3aS,7aR)-1-[(E,2R,5S)-5-hydroxy-5,6-dimethylhept-3-en-2-yl]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidenecyclohexane-1,3-diol
• CAS: 156316-85-7
• 化学式: C₂₈H₄₄O₃
• 分子量: 428.6
• InChiKey: ODZFJAXAEXQSKL-WRJREGAQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  31
• 可旋转键数：
  5
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  60.7
• 氢给体数：
  3
• 氢受体数：
  3

文献信息

• Methods for preparation and use of 1alpha,24(S)-dihydroxyvitamin D2
  申请人：Bone Care International, Inc.

  公开号：US20040009958A1

  公开（公告）日：2004-01-15

  A method of inhibiting the hyperproliferation of malignant or neoplastic cells, comprising treating the cells with an antiproliferative amount of 1&agr;,24(S)-dihydroxyvitamin D 2 . The method also includes the co-administration of cyotoxic agents with the 1&agr;,24(S)-dihydroxyvitamin D 2 .

  一种抑制恶性或肿瘤细胞过度增殖的方法，包括使用抗增殖量的1&agr;，24(S)-二氢维生素D2处理细胞。该方法还包括与1&agr;，24(S)-二氢维生素D2共同给药细胞毒剂。
• Methods for preparation of 1 alpha, 24-dihydroxy vitamin D2
  申请人：BONE CARE INTERNATIONAL, INC.

  公开号：EP0914825A2

  公开（公告）日：1999-05-12

  1α,24-dihydroxy vitamin D2 which is useful as an active compound of pharmaceutical compositions for the treatment of disorders of calcium metabolism and for various skin disorders. The invention also includes preparation of synthetic 1α,24-dihydroxy vitamin D2 starting from ergosterol which is converted in six steps to 24-hydroxyergosterol. 24-hydroxyergosterol is irradiated and thermally converted to 24-hydroxy vitamin D2 which is converted in five steps to 1α,24-dihydroxy vitamin D2. The syntheses also produce novel intermediates.

  1α,24-二羟基维生素 D2 可作为药物组合物的活性化合物，用于治疗钙代谢紊乱和各种皮肤病。本发明还包括制备合成的 1α,24-二羟基维生素 D2，它以麦角甾醇为原料，经过六个步骤转化为 24-羟基麦角甾醇。24- 羟基麦角甾醇经过辐照和热转化为 24- 羟基维生素 D2，再经过五个步骤转化为 1α,24-二羟基维生素 D2。合成过程中还会产生新的中间产物。
• Method of inhibiting angiogenesis using active vitamin D analogues
  申请人：Bone Care International, Inc.

  公开号：US20020019375A1

  公开（公告）日：2002-02-14

  Methods utilizing active vitamin D analogs for the inhibition of angiogenesis associated with malignant and neoplasmic cells. Methods comprise the application of an effective amount of a hypocalcemic vitamin D compound to inhibit the angiogenesis of malignant cells, inducing the apoptosis of malignant cells, and regressing the growth of tumorous cells.

  利用活性维生素 D 类似物抑制与恶性和肿瘤细胞相关的血管生成的方法。方法包括应用有效量的低钙维生素 D 化合物来抑制恶性细胞的血管生成，诱导恶性细胞凋亡，抑制肿瘤细胞的生长。
• Method of treating hyperproliferative diseases using active vitamin D analogues
  申请人：Bone Care International, Inc.

  公开号：US20020025950A1

  公开（公告）日：2002-02-28

  Methods for the utilization of hypocalcemic vitamin D analogs to inhibit the hyperproliferation of malignant or neoplastic cells without incidence of hypercalcemia.

  利用低钙维生素 D 类似物抑制恶性或肿瘤细胞过度增殖而不引起高钙血症的方法。
• Crystalline1alpha,24(S)-dihydroxyvitamin D2 and method of purification thereof
  申请人：Wisconsin Alumni Research Foundation

  公开号：US20010051738A1

  公开（公告）日：2001-12-13

  A method of purifying 1&agr;,24(S)-dihydroxyvitamin D 2 to obtain 1&agr;,24(S)-dihydroxyvitamin D 2 in crystalline form. The method includes the steps of boiling a solvent under inert atmosphere, dissolving a product containing 1&agr;,24(S)-dihydroxyvitamin D 2 to be purified in the solvent, cooling the solvent and dissolved product below ambient temperature for a sufficient amount of time to form a precipitate of 1&agr;,24(S)-dihydroxyvitamin D 2 crystals, and recovering the 1&agr;,24(S)-dihydroxyvitamin D 2 crystals. The purification technique involves using one of several binary solvent systems, namely, acetone and hexane, 2-propanol and hexane, or ethyl formate and petroleum ether.

  一种提纯 1&agr;,24(S)-二羟维生素 D 的方法 2 以获得 1&agr;,24(S)-二羟维生素 D 2 的晶体。该方法包括以下步骤：在惰性气氛下沸腾溶剂，溶解含有 1&agr;,24(S)-二羟基维生素 D 2 的产品溶解在溶剂中，将溶剂和溶解的产品冷却到环境温度以下足够长的时间，以形成 1&agr;,24(S)-二羟维生素 D 2 晶体，然后回收 1&agr;,24(S)-二羟维生素 D 2 晶体。纯化技术包括使用几种二元溶剂系统之一，即丙酮和正己烷、2-丙醇和正己烷或甲酸乙酯和石油醚。