1-(1-(5-bromopyridin-3-yl)-3-methyl-1H-benzo[f]chromen-2-yl)ethan-1-one | 1601493-15-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 萘并吡喃类
• 英文名称: 1-(1-(5-bromopyridin-3-yl)-3-methyl-1H-benzo[f]chromen-2-yl)ethan-1-one
• CAS: 1601493-15-5
• 化学式: C₂₁H₁₆BrNO₂
• 分子量: 394.268
• InChiKey: KPYIXMGQJKQVPD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.38
• 重原子数：
  25.0
• 可旋转键数：
  2.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  39.19
• 氢给体数：
  0.0
• 氢受体数：
  3.0

反应信息

• 作为产物：
  描述：

  5-溴吡啶-3-甲醛 、 乙酰丙酮 、 2-萘酚 在 cerium impregnated on MCM-41 作用下， 以 neat (no solvent) 为溶剂， 反应 0.75h， 以88%的产率得到1-(1-(5-bromopyridin-3-yl)-3-methyl-1H-benzo[f]chromen-2-yl)ethan-1-one
  参考文献：
  名称：

  Formation of benzoxanthenones and benzochromenones via cerium-impregnated-MCM-41 catalyzed, solvent-free, three-component reaction and their biological evaluation as anti-microbial agents

  摘要：

  We report here, three-component condensation reaction of naphthols, aldehydes and 1,3-dicarbonyl compounds catalyzed by Ce-MCM-41 under solvent-free conditions. Several advantages can be perceived using this eco-friendly protocol such as, a green and cost-effective procedure with excellent yield, shorter reaction time, simpler work-up, recovery and reusability of solid acid heterogeneous catalyst and tolerance towards a wide range of functional groups. We also report here the anti-microbial activities of the new compounds. Particularly, it was found that the new compounds have shown promising effect on Pseudo monal infections. (C) 2014 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.molcata.2014.02.012