2-(p-fluorobenzyl)-3-[p-(2-(1-piperidino)ethoxy)phenyl]-6-methoxybenzo[b]thiophene | 1229777-35-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻吩类
• 英文名称: 2-(p-fluorobenzyl)-3-[p-(2-(1-piperidino)ethoxy)phenyl]-6-methoxybenzo[b]thiophene
• 英文别名: 1-[2-[4-[2-[(4-Fluorophenyl)methyl]-6-methoxy-1-benzothiophen-3-yl]phenoxy]ethyl]piperidine
• CAS: 1229777-35-8
• 化学式: C₂₉H₃₀FNO₂S
• 分子量: 475.627
• InChiKey: BSBFJPUGJTVOMA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.4
• 重原子数：
  34
• 可旋转键数：
  8
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  49.9
• 氢给体数：
  0
• 氢受体数：
  5

文献信息

• 2-Benzyl-3-Arylbenzothiophenes useful for the treatment of post-menopausal syndrome
  申请人：ELI LILLY AND COMPANY

  公开号：EP0729955A1

  公开（公告）日：1996-09-04

  The present invention provides a compound of formula I wherein-    R1 is hydrogen, a hydroxy protecting group, or methyl;    R2 and R3 are independently C1-C6 alkyl, or R2 and R3, together with the nitrogen to which they are attached, form a heterocycle selected from the group consisting of pyrrolidino, hexamethyleneimino, morpholino, and piperidino;    Z is bromo, chloro, fluoro, hydroxy, a protected hydroxy, or hydrogen; and pharmaceutically acceptable salts and solvates thereof. The present invention further provides pharmaceutical compositions containing compounds of formula I, optionally containing estrogen or progestin, and the use of such compounds alone, or in combination with estrogen or progestin, for alleviating the symptoms of post-menopausal syndrome, particularly osteoporosis, cardiovascular related pathological conditions, and estrogen-dependent cancer. The compounds of the present invention also are useful for inhibiting uterine fibroid disease and endometriosis in women and aortal smooth muscle cell proliferation, particularly restenosis, in humans. Also encompassed are novel intermediates.

  本发明提供了一种式 I 的化合物 其中 R1 是氢、羟基保护基团或甲基； R2和R3独立地为C1-C6烷基，或R2和R3与它们所连接的氮一起形成一个杂环，该杂环选自由吡咯烷基、六亚甲基亚氨基、吗啉基和哌啶基组成的组； Z 是溴、氯、氟、羟基、受保护的羟基或氢；及其药学上可接受的盐和溶剂。 本发明进一步提供了含有式 I 化合物、任选含有雌激素或孕激素的药物组合物，以及此类化合物单独使用或与雌激素或孕激素联合使用，用于缓解绝经后综合征的症状，特别是骨质疏松症、心血管相关病理状况和雌激素依赖性癌症。 本发明的化合物还可用于抑制妇女的子宫肌瘤疾病和子宫内膜异位症，以及人的主动脉平滑肌细胞增殖，特别是再狭窄。 本发明还包括新型中间体。
• US5552401A
  申请人：——

  公开号：US5552401A

  公开（公告）日：1996-09-03
• US5643896A
  申请人：——

  公开号：US5643896A

  公开（公告）日：1997-07-01
• [EN] 2-BENZYL-3-ARYLBENZOTHIOPHENES<br/>[FR] 2-BENZYLE-3-ARYLBENZOTHIOPHENES
  申请人：ELI LILLY AND COMPANY

  公开号：WO1996026935A1

  公开（公告）日：1996-09-06

  (EN) The present invention provides derivatives of 2-phenylmethyl-3-[4-(2-aminoethoxy)phenyl]-benzo[b]thiophene. The present invention further provides pharmaceutical compositions containing these derivatives and the use of such compounds alone, or in combination with estrogen or progestin, for alleviating the symptoms of post-menopausal syndrome, particularly osteoporosis, cardiovascular related pathological conditions, and estrogen-dependent cancer. These compounds are also useful for inhibiting uterine fibroid disease and endometriosis in women and aortal smooth muscle cell proliferation, particularly restenosis, in humans.(FR) L'invention concerne des dérivés de 2-phénylméthyle-3-(4-(2-aminoéthoxy-phényle)-benzo(b)thiophène. L'invention traite également de compositions pharmaceutiques contenant ces dérivés et l'utilisation de tels composés seuls, ou en association avec des oestrogènes ou de la progestine pour traiter des symptômes tels que les syndromes des femmes ménopausées, en particulier l'ostéoporose, des troubles pathologiques liés aux problèmes cardiovasculaires, et le cancer oestrogéno-dépendant. Ces composés permettent également d'inhiber des maladies telles que les fibromes utérins et l'endométriose chez la femme, et la prolifération des cellules des muscles lisses aortiques, en particulier, la resténose chez l'humain.