[PtCl2(2-(4-chlorophenyl)-4-(4-methoxyphenyl)-6-(thiophen-2-yl)pyridine)] | 1601335-19-6

• 英文名称: [PtCl2(2-(4-chlorophenyl)-4-(4-methoxyphenyl)-6-(thiophen-2-yl)pyridine)]
• 英文别名: [PtCl₂(2-(4-chlorophenyl)-4-(4-methoxyphenyl)-6-(thiophen-2-yl)pyridine)]
• CAS: 1601335-19-6
• 化学式: C₂₂H₁₆Cl₃NOPtS
• 分子量: 643.88
• InChiKey: SHAWRJIPEVRCAQ-UHFFFAOYSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
  None
• 可旋转键数：
  None
• 环数：
  None
• sp3杂化的碳原子比例：
  None
• 拓扑面积：
  None
• 氢给体数：
  None
• 氢受体数：
  None

反应信息

• 作为产物：
  描述：

  2-乙酰基噻吩 在 盐酸 、 ammonium acetate 、 碘 作用下， 以 甲醇 、 水 为溶剂， 反应 1.0h， 生成 [PtCl2(2-(4-chlorophenyl)-4-(4-methoxyphenyl)-6-(thiophen-2-yl)pyridine)]
  参考文献：
  名称：

  DNA interaction and cytotoxic activities of square planar platinum(II) complexes with N, S-donor ligands

  摘要：

  The platinum(II) complexes with N, S-donor ligands have been synthesized and characterized by physicochemical methods viz, elemental, electronic, FT-IR, H-1 NMR and LC-MS spectra. The binding mode and potency of the complexes with HS DNA (Herring Sperm) have been examined by absorption titration and viscosity measurement studies. The results revealed that complexes bind to HS DNA via covalent mode with the intrinsic binding constant (K-b) in the range 1.37-7.76 x 10(5) M-1. Decrease in the relative viscosity of HS DNA also supports the covalent mode of binding. The DNA cleavage activity of synthesized complexes has been carried out by gel electrophoresis experiment using supercoiled form of pUC19 DNA; showing the unwinding of the negatively charged supercoiled DNA. Brine shrimp (Anemia Cysts) lethality bioassay technique has been applied for the determination of toxic property of synthesized complexes in terms of (C) 2014 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.saa.2014.02.053